Evidence map›Paper›PMID 33474504›Full record

ArticleHeliyon2021

Hepatotoxicity prevention in Acetaminophen-induced HepG2 cells by red betel (

Chrismis Novalinda Ginting, I Nyoman Ehrich Lister, Ermi Girsang, Wahyu Widowati, Dewani Tediana Yusepany, Alya Mardhotillah Azizah, Hanna Sari Widya Kusuma

Abstract read
In one paragraph

Article in Heliyon, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Mechanism of the effect ofOpen veterinary journal · 2025
    Article
  4. Hepatoprotective effects ofIranian journal of basic medical sciences · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Chrismis Novalinda GintingFaculty of Medicine, Universitas Prima Indonesia, Jl. Belanga No. 1, Medan 20118, North Sumatera, Indonesia.
I Nyoman Ehrich ListerFaculty of Medicine, Universitas Prima Indonesia, Jl. Belanga No. 1, Medan 20118, North Sumatera, Indonesia.
Ermi GirsangFaculty of Medicine, Universitas Prima Indonesia, Jl. Belanga No. 1, Medan 20118, North Sumatera, Indonesia.
Wahyu WidowatiFaculty of Medicine, Maranatha Christian University, Jl. Prof. Drg. Surya Sumantri No. 65, Bandung 40163, West Java, Indonesia.
Dewani Tediana YusepanyAretha Medika Utama, Biomolecular Research Center, Jl. Babakan Jeruk II No.9, Bandung 40163, West Java, Indonesia.
Alya Mardhotillah AzizahAretha Medika Utama, Biomolecular Research Center, Jl. Babakan Jeruk II No.9, Bandung 40163, West Java, Indonesia.
Hanna Sari Widya KusumaAretha Medika Utama, Biomolecular Research Center, Jl. Babakan Jeruk II No.9, Bandung 40163, West Java, Indonesia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acetaminophen (APAP) is a widely used analgesic, but it may cause liver injury (

Indexed as

AcetaminophenBiochemistryHepatoprotectiveHepG2 cellsImmunologyInflammationNatural productPharmaceutical scienceRed betel leaves extract

Identifiers

PMID33474504
PMCPMC7803640

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.