Evidence map›Paper›PMID 33473326›Full record

ArticleMolecular therapy. Nucleic acids2021

Adeno-associated virus-mediated delivery of anti-miR-199a tough decoys attenuates cardiac hypertrophy by targeting

Hualin Yan, Hong Wang, Xiaoxia Zhu, Jianbo Huang, Yifei Li, Kaiyu Zhou, Yimin Hua, Feng Yan, Da-Zhi Wang, Yan Luo

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular therapy. Nucleic acids, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 34 citations in OpenAlex.

  1. Review
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  12. Molecular Basis of Cardiomyopathies in Type 2 Diabetes.International journal of molecular sciences · 2024
    Review
  13. Article
  14. Current RNA strategies in treating cardiovascular diseases.Molecular therapy : the journal of the American Society of Gene Therapy · 2024
    Review
  15. Review
  16. Article
  17. Targeting miR-199a reduces fibrosis in hypertrophic cardiomyopathy.Journal of molecular and cellular cardiology plus · 2024
    Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Hualin YanDepartment of Medical Ultrasound, Laboratory of Ultrasound Imaging Drug, West China Hospital, Sichuan University, Chengdu 610041, China.
Hong WangDepartment of Medical Ultrasound, Laboratory of Ultrasound Imaging Drug, West China Hospital, Sichuan University, Chengdu 610041, China.
Xiaoxia ZhuDepartment of Medical Ultrasound, Laboratory of Ultrasound Imaging Drug, West China Hospital, Sichuan University, Chengdu 610041, China.
Jianbo HuangDepartment of Medical Ultrasound, Laboratory of Ultrasound Imaging Drug, West China Hospital, Sichuan University, Chengdu 610041, China.
Yifei LiDepartment of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu 610041, China.
Kaiyu ZhouDepartment of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu 610041, China.
Yimin HuaDepartment of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu 610041, China.
Feng YanDepartment of Medical Ultrasound, Laboratory of Ultrasound Imaging Drug, West China Hospital, Sichuan University, Chengdu 610041, China.
Da-Zhi WangDepartment of Cardiology, Boston Children's Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA.
Yan LuoDepartment of Medical Ultrasound, Laboratory of Ultrasound Imaging Drug, West China Hospital, Sichuan University, Chengdu 610041, China.
Sichuan University · CNBoston Children's Hospital · US

Funding

MicroRNAs, cardiac function and cardiomyopathyR01HL138757 · NHLBI · UNIVERSITY OF SOUTH FLORIDA · PI WANG, DA-ZHI · 2017 to 2020
$2.1M
NHLBI NIH HHS R01 HL138757
6 · The paper itself

Abstract

MicroRNAs (miRNAs) are important regulators in the process of cardiac hypertrophy and heart failure. Previous studies have shown that miR-199a is upregulated in pressure-overload cardiac hypertrophy and that inhibition of miR-199a attenuates cardiac hypertrophy

Indexed as

adeno-associated viruscardiac hypertrophyheart failuremicroRNA-199aPGC1-alpha

Identifiers

PMID33473326
PMCPMC7787996
OpenAlexW3103249110

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.