Evidence map›Paper›PMID 33473248›Full record

ArticleFrontiers in neurology2020

Delayed-Release Dimethyl Fumarate Safety and Efficacy in Pediatric Patients With Relapsing-Remitting Multiple Sclerosis.

Raed Alroughani, Peter Huppke, Maria Mazurkiewicz-Beldzinska, Astrid Blaschek, Martin Valis, Gregory Aaen, Joe Pultz, Xiaomei Peng, Vanessa Beynon

Abstract read
In one paragraph

Article in Frontiers in neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Trial
  2. Pediatric multiple sclerosis: Improving outcome through high-efficacy therapies.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025
    Review
  3. Review
  4. Therapeutic Advances in Pediatric Multiple Sclerosis.Children (Basel, Switzerland) · 2025
    Review
  5. Article
  6. Review
  7. Observational
  8. Review
  9. Article
  10. Review
  11. Review
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Raed AlroughaniDasman Diabetes Institute, Dasman, Kuwait and Amiri Hospital, Sharq, Kuwait.
Peter HuppkeDepartment of Pediatrics and Pediatric Neurology, University Medical Center Göttingen, Göttingen, Germany.
Maria Mazurkiewicz-BeldzinskaKlinika Neurologii Rozwojowej, Uniwersyteckie Centrum Kliniczne, Gdansk, Poland.
Astrid BlaschekDepartment of Pediatric Neurology and Developmental Medicine, Hauner Children's Hospital, University of Munich, Munich, Germany.
Martin ValisNeurologicka klinika, Fakultni nemocnice Hradec Kralove, Hradec Kralove, Czechia.
Gregory AaenLoma Linda University Children's Health, Loma Linda, CA, United States.
Joe PultzBiogen, Cambridge, MA, United States.
Xiaomei PengBiogen, Cambridge, MA, United States.
Vanessa BeynonBiogen, Cambridge, MA, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

dimethyl fumarateefficacypediatricpharmacokineticsrelapsing-remitting multiple sclerosissafety

Identifiers

PMID33473248
PMCPMC7812971

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.