Evidence map›Paper›PMID 33473245›Full record

ArticleFrontiers in cellular neuroscience2020

Organotypic Brain Slice Culture Microglia Exhibit Molecular Similarity to Acutely-Isolated Adult Microglia and Provide a Platform to Study Neuroinflammation.

Alex R D Delbridge, Dann Huh, Margot Brickelmaier, Jeremy C Burns, Chris Roberts, Ravi Challa, Naideline Raymond, Patrick Cullen, Thomas M Carlile, Katelin A Ennis and 9 more

Abstract read
In one paragraph

Article in Frontiers in cellular neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed.

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  9. Review
  10. Article
  11. Emerging Roles of Bile Acids in Neuroinflammation.International journal of molecular sciences · 2025
    Review
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Alex R D DelbridgeMultiple Sclerosis and Neuroimmunology Research Unit, Biogen, Cambridge, MA, United States.
Dann HuhTranslational Biology, Biogen, Cambridge, MA, United States.
Margot BrickelmaierMultiple Sclerosis and Neuroimmunology Research Unit, Biogen, Cambridge, MA, United States.
Jeremy C BurnsMultiple Sclerosis and Neuroimmunology Research Unit, Biogen, Cambridge, MA, United States.
Chris RobertsTranslational Biology, Biogen, Cambridge, MA, United States.
Ravi ChallaTranslational Biology, Biogen, Cambridge, MA, United States.
Naideline RaymondMultiple Sclerosis and Neuroimmunology Research Unit, Biogen, Cambridge, MA, United States.
Patrick CullenTranslational Biology, Biogen, Cambridge, MA, United States.
Thomas M CarlileTranslational Biology, Biogen, Cambridge, MA, United States.
Katelin A EnnisGenetic and Neurodevelopmental Disorders, Biogen, Cambridge, MA, United States.
Mei LiuBiogen Postdoctoral Scientist Program, Biogen, Cambridge, MA, United States.
Chao SunBiogen Postdoctoral Scientist Program, Biogen, Cambridge, MA, United States.
Normand E AllaireBiogen Postdoctoral Scientist Program, Biogen, Cambridge, MA, United States.
Marianna FoosBiogen Postdoctoral Scientist Program, Biogen, Cambridge, MA, United States.
Hui-Hsin TsaiMultiple Sclerosis and Neuroimmunology Research Unit, Biogen, Cambridge, MA, United States.
Nathalie FranchimontMS Immunology Development Unit, Biogen, Cambridge, MA, United States.
Richard M RansohoffMultiple Sclerosis and Neuroimmunology Research Unit, Biogen, Cambridge, MA, United States.
Cherie ButtsDigital & Quantitative Medicine, Biogen, Cambridge, MA, United States.
Michael MingueneauMultiple Sclerosis and Neuroimmunology Research Unit, Biogen, Cambridge, MA, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Microglia are central nervous system (CNS) resident immune cells that have been implicated in neuroinflammatory pathogenesis of a variety of neurological conditions. Their manifold context-dependent contributions to neuroinflammation are only beginning to be elucidated, which can be attributed in part to the challenges of studying microglia

Indexed as

brain slice culturechemokinecytokineGM-CSFLPSmicroglianeuroinflammationTNF

Identifiers

PMID33473245
PMCPMC7812919

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.