Evidence map›Paper›PMID 33473217›Full record

ArticleNature2021

Wetting regulates autophagy of phase-separated compartments and the cytosol.

Jaime Agudo-Canalejo, Sebastian W Schultz, Haruka Chino, Simona M Migliano, Chieko Saito, Ikuko Koyama-Honda, Harald Stenmark, Andreas Brech, Alexander I May, Noboru Mizushima and 1 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 144 papers.

0numbers the graph read from it
0cells of the map it votes in
144citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

144 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Capillary bundling of microtubules by condensates.bioRxiv : the preprint server for biology · 2026
    Article
  9. The Human Autophagy Core Complexes.Annual review of biochemistry · 2026
    Review
  10. Review
  11. Review
  12. Article
  13. Review
  14. Article
  15. Condensate-mediated shape transformations of cellular membranes by capillary forces.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  16. Review
  17. Article
  18. Review
  19. Core principles of autophagy initiation mechanisms.Nature structural & molecular biology · 2026
    Review
  20. Article

84 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Jaime Agudo-Canalejo *Rudolf Peierls Centre for Theoretical Physics, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0001-9677-6054
Sebastian W Schultz *Department of Molecular Cell Biology, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway.ORCID http://orcid.org/0000-0002-3661-2178
Haruka ChinoGraduate School and Faculty of Medicine, The University of Tokyo, Tokyo, Japan.
Simona M MiglianoDepartment of Molecular Cell Biology, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway.ORCID http://orcid.org/0000-0002-1888-5332
Chieko SaitoGraduate School and Faculty of Medicine, The University of Tokyo, Tokyo, Japan.ORCID http://orcid.org/0000-0002-4374-5120
Ikuko Koyama-HondaGraduate School and Faculty of Medicine, The University of Tokyo, Tokyo, Japan.ORCID http://orcid.org/0000-0001-9321-9682
Harald StenmarkDepartment of Molecular Cell Biology, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway.ORCID http://orcid.org/0000-0002-1971-4252
Andreas BrechDepartment of Molecular Cell Biology, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway.ORCID http://orcid.org/0000-0002-9803-1774
Alexander I MayCell Biology Center, Institute of Innovative Research, Tokyo Institute of Technology, Yokohama, Japan.
Noboru MizushimaGraduate School and Faculty of Medicine, The University of Tokyo, Tokyo, Japan.ORCID http://orcid.org/0000-0002-6258-6444
Roland L KnorrGraduate School and Faculty of Medicine, The University of Tokyo, Tokyo, Japan. knorr@m.u-tokyo.ac.jp.ORCID http://orcid.org/0000-0002-6747-0088

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Compartmentalization of cellular material in droplet-like structures is a hallmark of liquid-liquid phase separation

Indexed as

AutophagyCell CompartmentationWettabilityAdhesivenessAutophagosomesCell LineCytosolHumansIntracellular MembranesSequestosome-1 ProteinSurface TensionSequestosome-1 ProteinSQSTM1 protein, human

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.