ArticleNature2021
Restoring metabolism of myeloid cells reverses cognitive decline in ageing.
Registry-linked trialOpen access · greenAbstract read
In one paragraph
Article in Nature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06869941 (Adipose Tissue Gene Expression and Metabolomics Links to the Gut Microbiome-brain Axis), which is not on this map. Cited by 321 papers.
0numbers the graph read from it
0cells of the map it votes in
321citing papers in PubMed
38.0field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Adipose Tissue Gene Expression and Metabolomics Links to the Gut Microbiome-brain Axis (POINSETTIA Study)
Who cites it
321 citing papers in PubMed, 506 citations in OpenAlex.
- Guilingji capsule for Alzheimer's disease: secondary analysis of a randomized non-inferiority controlled trial.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2023Trial
- The endocannabinoid system and the ageing brain.Nature reviews. Neuroscience · 2026Review
- An aging-sensitive secreted phospholipase confers neuroprotection and cognitive resilience.Nature neuroscience · 2026Article
- PPARγ Signaling in the Central Nervous System: A Review of the Implications in Synaptic Plasticity, Neuroinflammatory and Neoplastic Processes.Neurochemical research · 2026Review
- The mitochondrial epigenome and noncoding genome in aging and brain diseases.Trends in neurosciences · 2026Review
- Prostaglandin E2-mediated aging microenvironment fuels pathogenic fibrosis in cesarean section scar defect.EMBO molecular medicine · 2026Article
- Spatiotemporal heterogeneity and dynamic evolution of microglial glucose metabolic reprogramming in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Review
- The Hallmarks of Aging: From Molecular Mechanisms to Clinical Translation.International journal of molecular sciences · 2026Review
- Review
- Fat on Fire: Disrupted Microglial Lipid Metabolism as a Driver of Anesthetic Neurotoxicity.Neuroscience bulletin · 2026Review
- Targeting Mitochondrial Dysfunction in Microglia: A New Frontier for Treating Neurodegenerative Diseases.Molecular neurobiology · 2026Review
- Lipidomic profiling reveals age-dependent changes in plasma membrane lipids that affect neural stem cell aging.Science advances · 2026Article
- Reprogramming senescent granulosa cells for germ-cell generation.Science China. Life sciences · 2026Article
- Reduced LACTB expression in myeloid cells is associated with elevated succinylcarnitine and reduced Alzheimer's disease risk.Research square · 2026Article
- Microglial mitophagy as an immunometabolic checkpoint in alzheimer's disease: linking mitochondrial quality control to neuroinflammation.Journal of neuroinflammation · 2026Review
- Clinical Determinants and Bone Metabolic Correlates of 24-h Urinary PGE2 and PGEM Excretion in Chinese Adults: A Multicenter Cross-Sectional Study.Biomedicines · 2026Article
- Development of highly potent EP2 antagonists as novel anti-inflammatory neuroprotectants.Bioorganic & medicinal chemistry · 2026Article
- Age-Associated Senescence of Decidual Macrophages: A Key Mediator of Adverse Pregnancy Outcomes in Advanced Maternal Age.Aging cell · 2026Article
- Laser-Engineered Ag Nanoparticle on Carbon Cloth Electrodes for Enzyme-Free Electrochemical NADSmall (Weinheim an der Bergstrasse, Germany) · 2026Article
- PYGL-driven glycogenolysis impairs microglial autophagic fluxActa pharmaceutica Sinica. B · 2026Article
261 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
21 authors at 4 institutions in 2 countries.
Paras S MinhasDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.
Amira Latif-Hernandez *Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.
Melanie R McReynolds *Department of Chemistry, Princeton University, Princeton, NJ, USA.ORCID http://orcid.org/0000-0001-5427-2739
Aarooran S DurairajDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.
Qian WangDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.
Amanda RubinDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.
Amit U JoshiDepartment of Chemical and Systems Biology, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-2472-7672
Joy Q HeInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Esha GaubaDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.
Ling LiuDepartment of Chemistry, Princeton University, Princeton, NJ, USA.
Congcong WangDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-6471-3865
Miles LindeDepartment of Hematology, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0003-2553-2890
Yuki SugiuraDepartment of Biochemistry, Keio University School of Medicine, Tokyo, Japan.
Peter K MoonDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.
Ravi MajetiDepartment of Hematology, Stanford University School of Medicine, Stanford, CA, USA.
Makoto SuematsuDepartment of Biochemistry, Keio University School of Medicine, Tokyo, Japan.ORCID http://orcid.org/0000-0002-7165-6336
Daria Mochly-RosenDepartment of Chemical and Systems Biology, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-6691-8733
Irving L WeissmanInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-9077-7467
Frank M LongoDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.
Joshua D RabinowitzDepartment of Chemistry, Princeton University, Princeton, NJ, USA.ORCID http://orcid.org/0000-0002-1247-4727
Katrin I AndreassonDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA. kandreas@stanford.edu.ORCID http://orcid.org/0000-0001-8391-4155
Stanford University · USPrinceton University · USKeio University · JPNeurosciences Institute · US
Funding
Stanford Alzheimer's Disease Research CenterAdmin Supp: Developing iPSC models for AD and PDP30AG066515 · NIA · STANFORD UNIVERSITY · PI Victor Henderson · 2020 to 2026
$29.0MWorking Memory in Parkinson Disease: A Cognitive & Systems Neuroscience ApproachP50AG047366 · NIA · STANFORD UNIVERSITY · PI GREICIUS, MICHAEL D · 2015 to 2019
$7.9MStem Cell Biology, Cancer Stem Cell Biology, and Cancer ImmunotherapyR35CA220434 · NCI · STANFORD UNIVERSITY · PI WEISSMAN, IRVING L. · 2017 to 2023
$6.7MMetabolism in Action: Quantitative Fluxes in MammalsDP1DK113643 · NIDDK · PRINCETON UNIVERSITY · PI RABINOWITZ, JOSHUA D · 2016 to 2020
$5.7MTargeting the kynurenine pathway in Alzheimer's diseaseR01AG048232 · NIA · STANFORD UNIVERSITY · PI ANDREASSON, KATRIN I. · 2014 to 2018
$2.4MRegulation of immune cell metabolism in aging and Alzheimer's disease: role of the kynurenine pathwayRF1AG058047 · NIA · STANFORD UNIVERSITY · PI ANDREASSON, KATRIN I. · 2017 to 2017
$2.0MMicroglial and macrophage PGE2 signaling in post-stroke inflammationR21NS087639 · NINDS · STANFORD UNIVERSITY · PI ANDREASSON, KATRIN I. · 2014 to 2015
$449kDEFINING THE MEDULLOBLASTOMA CANCER STEM CELL LINEAGE HIERARCHY BY NOTCH SIGNALINGF30CA228215 · NCI · STANFORD UNIVERSITY · PI HE, JOY · 2018 to 2021
$132kAmerican Heart Association-American Stroke AssociationNCI NIH HHS F30 CA228215NCI NIH HHS R35 CA220434NIA NIH HHS P30 AG066515NIA NIH HHS P50 AG047366NIA NIH HHS R01 AG048232NIA NIH HHS RF1 AG058047NIDDK NIH HHS DP1 DK113643NIH HHS 1S10RR02678001NINDS NIH HHS R21 NS087639Wellcome Trust
Abstract
Ageing is characterized by the development of persistent pro-inflammatory responses that contribute to atherosclerosis, metabolic syndrome, cancer and frailty
Indexed as
AdultAgedAgingAnimalsCell RespirationCells, CulturedCognitive DysfunctionDinoprostoneEnergy MetabolismGlucoseGlycogenHumansInflammationMacrophagesMemory DisordersMiceDinoprostoneGlucoseGlycogenReceptors, Prostaglandin E, EP2 Subtype
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
NCT06869941ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.