ArticleAsian journal of andrology
Glutathione (GSH) improves sperm quality and testicular morphology in streptozotocin-induced diabetic mice.
Article in Asian journal of andrology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 30 citations in OpenAlex.
- OralWorld journal of diabetes · 2025Article
- Understanding the impact of streptozotocin on diabetic male infertility: perspectives from rodent models and pharmacological networking.BMC pharmacology & toxicology · 2025Review
- Melatonin as a potential adjuvant to mitigate depakine‑induced testicular damage in rats through its biological features.BMC complementary medicine and therapies · 2025Article
- Role of Redox-Induced Protein Modifications in Spermatozoa in Health and Disease.Antioxidants (Basel, Switzerland) · 2025Review
- Protective effects of lupeol on pesticides induced testicular and oxidative damage of male rats.Journal of molecular histology · 2025Article
- Propolis mitigates busulfan-induced testicular dysfunction in rats: insights into redox stabilization, PCNA modulation, and caspase-3 inhibition.Frontiers in pharmacology · 2025Article
- The Potential Effect of Bualuang (WhiteLife (Basel, Switzerland) · 2024Article
- Evaluation of Selected Folk Herbs on the Fertility of Sprague Dawley Male Rats: Biochemical, Histological, and Molecular Investigations.Life (Basel, Switzerland) · 2024Article
- The Association Between the Levels of Oxidative Stress Indicators (MDA, SOD, and GSH) in Seminal Plasma and the Risk of Idiopathic Oligo-asthenotera-tozoospermia: Does Cu or Se Level Alter the Association?Biological trace element research · 2024Article
- Bezafibrate alleviates diabetes-induced spermatogenesis dysfunction by inhibiting inflammation and oxidative stress.Heliyon · 2024Article
- A Polyherbal Mixture with Nutraceutical Properties for Ruminants: A Meta-Analysis and Review of BioCholine Powder.Animals : an open access journal from MDPI · 2024Review
- Gss deficiency causes age-related fertility impairment via ROS-triggered ferroptosis in the testes of mice.Cell death & disease · 2023Article
- Dapagliflozin Mitigated Elevated Disomic and Diploid Sperm in a Mouse Model of Diabetes and Recover the DisruptedBiomedicines · 2023Article
- The Effects of Glutathione on Clinically Essential Fertility Parameters in a Bleomycin Etoposide Cisplatin Chemotherapy Model.Life (Basel, Switzerland) · 2023Article
- Review
- Nicotinamide mononucleotide improves spermatogenic function in streptozotocin-induced diabetic mice via modulating the glycolysis pathway.Acta biochimica et biophysica Sinica · 2022Article
- Reprotoxic Impact of Environment, Diet, and Behavior.International journal of environmental research and public health · 2022Review
- Effect of Glutathione on Sperm Quality in Guanzhong Dairy Goat Sperm During Cryopreservation.Frontiers in veterinary science · 2021Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diabetes mellitus (DM) is known to cause reproductive impairment. In men, it has been linked to altered sperm quality and testicular damage. Oxidative stress (OS) plays a pivotal role in the development of DM complications. Glutathione (GSH) is a part of a nonenzymatic antioxidant defense system that protects lipid, protein, and nucleic acids from oxidative damage. However, the protective effects of exogenous GSH on the male reproductive system have not been comprehensively examined. This study determined the impact of GSH supplementation in ameliorating the adverse effect of type 1 DM on sperm quality and the seminiferous tubules of diabetic C57BL/6NTac mice. GSH at the doses of 15 mg kg
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.