Evidence map›Paper›PMID 33472983›Full record

ArticlemSphere2021

Phenotypic and Genotypic Adaptations in Pseudomonas aeruginosa Biofilms following Long-Term Exposure to an Alginate Oligomer Therapy.

Juliette L Oakley, Rebecca Weiser, Lydia C Powell, Julian Forton, Eshwar Mahenthiralingam, Philip D Rye, Katja E Hill, David W Thomas, Manon F Pritchard

Open access · goldAbstract read
In one paragraph

Article in mSphere, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Genetic diversification ofApplied and environmental microbiology · 2026
    Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Biologically Relevant Murine Models of ChronicPathogens (Basel, Switzerland) · 2023
    Article
  9. Review
  10. International journal of molecular sciences · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Juliette L OakleyAdvanced Therapies Group, Oral and Biomedical Sciences, School of Dentistry, College of Biomedical and Life Sciences, Cardiff University, Cardiff, United Kingdom.
Rebecca WeiserCardiff School of Bioscience, Cardiff University, Cardiff, United Kingdom.
Lydia C PowellAdvanced Therapies Group, Oral and Biomedical Sciences, School of Dentistry, College of Biomedical and Life Sciences, Cardiff University, Cardiff, United Kingdom.
Julian FortonDepartment of Paediatric Respiratory Medicine/Cystic Fibrosis Unit, Children's Hospital for Wales, Cardiff, United Kingdom.
Eshwar MahenthiralingamCardiff School of Bioscience, Cardiff University, Cardiff, United Kingdom.ORCID 0000-0001-9014-3790
Philip D RyeAlgiPharma AS, Sandvika, Norway.
Katja E HillAdvanced Therapies Group, Oral and Biomedical Sciences, School of Dentistry, College of Biomedical and Life Sciences, Cardiff University, Cardiff, United Kingdom.ORCID 0000-0002-8590-0117
David W ThomasAdvanced Therapies Group, Oral and Biomedical Sciences, School of Dentistry, College of Biomedical and Life Sciences, Cardiff University, Cardiff, United Kingdom.
Manon F PritchardAdvanced Therapies Group, Oral and Biomedical Sciences, School of Dentistry, College of Biomedical and Life Sciences, Cardiff University, Cardiff, United Kingdom PritchardMF@cardiff.ac.uk.ORCID 0000-0002-5135-4744
Cardiff University · GBAlgiPharma (Norway) · NONoah's Ark Children's Hospital for Wales · GB

Funding

Medical Research Council 513400Wellcome TrustWellcome Trust 513087
6 · The paper itself

Abstract

Chronic

Indexed as

GenotypePhenotypeAdaptation, PhysiologicalAlginatesAnti-Bacterial AgentsBiofilmsDrug Resistance, Multiple, BacterialHumansMicrobial Sensitivity TestsPseudomonas aeruginosaPseudomonas InfectionsSputumTime FactorsAlginatesAnti-Bacterial Agentsalginate oligosaccharidebead modelbiofilmcystic fibrosisPseudomonas aeruginosa

Identifiers

PMID33472983
PMCPMC7845618
OpenAlexW3125444324

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.