Evidence map›Paper›PMID 33472981›Full record

ArticlemSphere2021

Decreased Ecological Resistance of the Gut Microbiota in Response to Clindamycin Challenge in Mice Colonized with the Fungus Candida albicans.

Laura Markey, Antonia Pugliese, Theresa Tian, Farrah Roy, Kyongbum Lee, Carol A Kumamoto

Open access · goldAbstract read
In one paragraph

Article in mSphere, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Laura MarkeyGraduate School of Biomedical Sciences, Tufts University School of Medicine, Boston, Massachusetts, USA.
Antonia PuglieseGraduate School of Biomedical Sciences, Tufts University School of Medicine, Boston, Massachusetts, USA.
Theresa TianDepartment of Chemical and Biological Engineering, Tufts University School of Engineering, Medford, Massachusetts, USA.
Farrah RoyDepartment of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
Kyongbum LeeDepartment of Chemical and Biological Engineering, Tufts University School of Engineering, Medford, Massachusetts, USA.
Carol A KumamotoDepartment of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, Massachusetts, USA carol.kumamoto@tufts.edu.ORCID 0000-0001-6352-4918
Tufts University · USHarvard University · US

Funding

Genetic and Genomic Characterization of the Occurrence and Progression of Interstitial Lung AbnormalitiesR01HL135142 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI MICHAEL H. CHO, GARY MATTHEW HUNNINGHAKE · 2017 to 2026
$7.7M
Unraveling the Complexities of Risk and Mechanism in CancerR35CA220523 · NCI · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI QUACKENBUSH, JOHN · 2018 to 2024
$6.0M
MOLECULAR ANALYSIS OF MICROBIAL PATHOGENST32AI007422 · NIAID · TUFTS UNIVERSITY BOSTON · PI Ralph R. Isberg · 1992 to 2026
$5.7M
C ALBICANS IN THE GI TRACT ENVIRONMENTR01AI118898 · NIAID · TUFTS UNIVERSITY BOSTON · PI KUMAMOTO, CAROL A. · 2016 to 2020
$2.5M
Molecular Genetics of Basic Cell FunctionT32GM139772 · NIGMS · TUFTS UNIVERSITY BOSTON · PI Andrew Camilli · 2022 to 2026
$1.3M
NCI NIH HHS R35 CA220523NHLBI NIH HHS R01 HL135142NIAID NIH HHS R01 AI118898NIAID NIH HHS T32 AI007422NIGMS NIH HHS T32 GM139772
6 · The paper itself

Abstract

The mammalian gut microbiota is a complex community of microorganisms which typically exhibits remarkable stability. As the gut microbiota has been shown to affect many aspects of host health, the molecular keys to developing and maintaining a "healthy" gut microbiota are highly sought after. Yet, the qualities that define a microbiota as healthy remain elusive. We used the ability to resist change in response to antibiotic disruption, a quality we refer to as ecological resistance, as a metric for the health of the bacterial microbiota. Using a mouse model, we found that colonization with the commensal fungus

Indexed as

AnimalsAnti-Bacterial AgentsCandida albicansCandidiasisCecumClindamycinDisease Models, AnimalFecesFemaleGastrointestinal MicrobiomeGenetic VariationMiceMice, Inbred C57BLAnti-Bacterial AgentsClindamycinCandida albicansecological resistancemicrobiota

Identifiers

PMID33472981
PMCPMC7845615
OpenAlexW3123157480

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.