Evidence map›Paper›PMID 33472955›Full record

ArticleScience translational medicine2021

Diet-induced obesity promotes infection by impairment of the innate antimicrobial defense function of dermal adipocyte progenitors.

Ling-Juan Zhang, Christian F Guerrero-Juarez, Stella X Chen, Xiaowei Zhang, Meimei Yin, Fengwu Li, Shuai Wu, Joyce Chen, Min Li, Yingzi Liu and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science translational medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed.

  1. Article
  2. PGEThe Journal of investigative dermatology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Ling-Juan ZhangState Key Laboratory of Cellular Stress Biology, School of Pharmaceutical Sciences, Xiamen University, Xiamen 361102, China. lingjuan.zhang@xmu.edu.cn rgallo@ucsd.edu.ORCID 0000-0001-6937-4578
Christian F Guerrero-JuarezNSF-Simons Center for Multiscale Cell Fate Research, University of California, Irvine, Irvine, CA 92697, USA.ORCID 0000-0002-6245-6412
Stella X ChenDepartment of Dermatology, University of California, San Diego, La Jolla, CA 92093, USA.ORCID 0000-0002-3453-4786
Xiaowei ZhangState Key Laboratory of Cellular Stress Biology, School of Pharmaceutical Sciences, Xiamen University, Xiamen 361102, China.ORCID 0000-0002-7095-5326
Meimei YinState Key Laboratory of Cellular Stress Biology, School of Pharmaceutical Sciences, Xiamen University, Xiamen 361102, China.ORCID 0000-0003-3718-1944
Fengwu LiDepartment of Dermatology, University of California, San Diego, La Jolla, CA 92093, USA.ORCID 0000-0001-5092-770X
Shuai WuState Key Laboratory of Cellular Stress Biology, School of Pharmaceutical Sciences, Xiamen University, Xiamen 361102, China.
Joyce ChenDepartment of Dermatology, University of California, San Diego, La Jolla, CA 92093, USA.ORCID 0000-0002-7317-7486
Min LiInstitute of Dermatology, Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Chinese Academy of Medical Science and Peking Union Medical College, Nanjing 210042, China.
Yingzi LiuDepartment of Mathematics, University of California, Irvine, Irvine, CA 92697, USA.ORCID 0000-0002-8704-4756
Shang I B JiangDepartment of Dermatology, University of California, San Diego, La Jolla, CA 92093, USA.
Tissa HataDepartment of Dermatology, University of California, San Diego, La Jolla, CA 92093, USA.
Maksim V PlikusNSF-Simons Center for Multiscale Cell Fate Research, University of California, Irvine, Irvine, CA 92697, USA.ORCID 0000-0002-8845-2559
Richard L GalloDepartment of Dermatology, University of California, San Diego, La Jolla, CA 92093, USA. lingjuan.zhang@xmu.edu.cn rgallo@ucsd.edu.ORCID 0000-0002-1401-7861

Funding

Targeted Microbiome Transplant in Atopic DermatitisU19AI117673 · NIAID · NATIONAL JEWISH HEALTH · PI GEHA, RAIF SALIM · 2015 to 2019
$30.6M
UCI P30 Skin Center Systems Biology CoreP30AR075047 · NIAMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI ANDERSEN, BOGI, GANESAN, ANAND K · 2019 to 2025
$5.1M
Cathelicidin in Skin ImmunityR37AI052453 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Richard L Gallo, Victor Nizet · 2019 to 2026
$4.6M
Multiscale Models of Wound Cell Plasticity for RegenerationU01AR073159 · NIAMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI DAI, XING, NIE, QING · 2018 to 2022
$3.5M
Inflammatory cross-talk between skin and gutR01DK128787 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GALLO, RICHARD L, SALZMAN, NITA H · 2021 to 2024
$2.6M
Conflict and Cooperation between AMP Species on the skinR01AR076082 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GALLO, RICHARD L, NAKATSUJI, TERUAKI · 2019 to 2023
$2.3M
Induction of fat regeneration in skin wounds by hair follicle signalingR01AR067273 · NIAMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI PLIKUS, MAKSIM V · 2014 to 2018
$1.9M
Skin Defense by Dermal AdipocytesR01AR069653 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GALLO, RICHARD L · 2016 to 2020
$1.9M
NIAID NIH HHS R37 AI052453NIAID NIH HHS U19 AI117673NIAMS NIH HHS P30 AR075047NIAMS NIH HHS R01 AR067273NIAMS NIH HHS R01 AR069653NIAMS NIH HHS R01 AR076082NIAMS NIH HHS U01 AR073159NIDDK NIH HHS R01 DK128787
6 · The paper itself

Abstract

Infections are a major complication of obesity, but the mechanisms responsible for impaired defense against microbes are not well understood. Here, we found that adipocyte progenitors were lost from the dermis during diet-induced obesity (DIO) in humans and mice. The loss of adipogenic fibroblasts from mice resulted in less antimicrobial peptide production and greatly increased susceptibility to

Indexed as

Anti-Infective Agents3T3-L1 CellsAdipocytesAnimalsCell DifferentiationDietDiet, High-FatMiceMice, Inbred C57BLObesityPPAR gammaStaphylococcal InfectionsStaphylococcus aureusTransforming Growth Factor betaAnti-Infective AgentsPPAR gammaTransforming Growth Factor beta

Identifiers

PMID33472955
PMCPMC8164450

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.