Evidence map›Paper›PMID 33472935›Full record

ArticleJournal of virology2021

Novel Lytic Phages Protect Cells and Mice against

Feng Chen, Xingjun Cheng, Jianbo Li, Xiefang Yuan, Xiuhua Huang, Mao Lian, Wenfang Li, Tianfang Huang, Yaliu Xie, Jie Liu and 4 more

Abstract read
In one paragraph

Article in Journal of virology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Complete genome sequences of threeMicrobiology resource announcements · 2025
    Article
  9. Article
  10. Review
  11. Article
  12. Review
  13. Review
  14. Journal of virology · 2024
    Article
  15. Viruses · 2024
    Review
  16. Review
  17. Article
  18. Review
  19. Frontiers in microbiology · 2024
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Feng ChenRespiratory Department, Allergy and Immunity Institute, Affiliated Hospital, Southwest Medical University, 646000, Luzhou, China.
Xingjun ChengState Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center of Biotherapy, Chengdu, 610041, China.
Jianbo LiRespiratory Department, Allergy and Immunity Institute, Affiliated Hospital, Southwest Medical University, 646000, Luzhou, China.
Xiefang YuanRespiratory Department, Allergy and Immunity Institute, Affiliated Hospital, Southwest Medical University, 646000, Luzhou, China.
Xiuhua HuangState Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center of Biotherapy, Chengdu, 610041, China.
Mao LianState Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center of Biotherapy, Chengdu, 610041, China.
Wenfang LiState Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center of Biotherapy, Chengdu, 610041, China.
Tianfang HuangChengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, 610041, China.
Yaliu XieDepartment of Otolaryngology, The Seventh People's Hospital of Chengdu, Chengdu, 610041, China.
Jie LiuState Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center of Biotherapy, Chengdu, 610041, China.
Pan GaoState Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center of Biotherapy, Chengdu, 610041, China.
Xiawei WeiState Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center of Biotherapy, Chengdu, 610041, China.
Zhenling WangState Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center of Biotherapy, Chengdu, 610041, China.; min.wu@und.edu wangzhenling@scu.edu.cn.ORCID https://orcid.org/0000-0003-0364-8948
Min WuRespiratory Department, Allergy and Immunity Institute, Affiliated Hospital, Southwest Medical University, 646000, Luzhou, China.; min.wu@und.edu wangzhenling@scu.edu.cn.ORCID https://orcid.org/0000-0003-1205-982X

Funding

Yersina perstis interactions with macrophagesP20GM113123 · NIGMS · UNIVERSITY OF NORTH DAKOTA · PI COMBS, COLIN K · 2016 to 2025
$19.9M
Lung innate immunity against bacterial infectionR01AI109317 · NIAID · UNIVERSITY OF NORTH DAKOTA · PI WU, MIN · 2014 to 2018
$1.7M
Long noncoding RNAs interact with miRNAs to regulate inflammatory responseR01AI138203 · NIAID · UNIVERSITY OF NORTH DAKOTA · PI COMBS, COLIN K · 2018 to 2021
$1.4M
Ceramide membrane microdomains regulate cytokine secretionR03AI097532 · NIAID · UNIVERSITY OF NORTH DAKOTA · PI SINGH, BRIJ B · 2012 to 2013
$138k
NIAID NIH HHS R01 AI109317NIAID NIH HHS R01 AI138203NIAID NIH HHS R03 AI097532NIGMS NIH HHS P20 GM113123
6 · The paper itself

Abstract

With the fast emergence of serious antibiotic resistance and the lagged discovery of novel antibacterial drugs, phage therapy for pathogenic bacterial infections has acquired great attention in the clinics. However, development of therapeutic phages also faces tough challenges, such as laborious screening and time to generate effective phage drugs since each phage may only lyse a narrow scope of bacterial strains. Identifying highly effective phages with broad host ranges is crucial for improving phage therapy. Here, we isolated and characterized several lytic phages from various environments specific for

Identifiers

PMID33472935
PMCPMC8103703

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.