Evidence map›Paper›PMID 33472930›Full record

ArticleJournal of virology2021

Reovirus RNA recombination is sequence directed and generates internally deleted defective genome segments during passage.

Sydni Caet Smith, Jennifer Gribble, Julia R Diller, Michelle A Wiebe, Timothy W Thoner, Mark R Denison, Kristen M Ogden

Open access · greenAbstract read
In one paragraph

Article in Journal of virology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 16 citations in OpenAlex.

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  6. Virion aggregation shapes infection dynamics and evolutionary potential.bioRxiv : the preprint server for biology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Sydni Caet SmithDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center.
Jennifer GribbleDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center.
Julia R DillerDepartment of Pediatrics, Vanderbilt University Medical Center.
Michelle A WiebeDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center.
Timothy W ThonerDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center.
Mark R DenisonDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center.
Kristen M OgdenDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center kristen.ogden@vumc.org.ORCID https://orcid.org/0000-0002-2670-4335
Vanderbilt University Medical Center · US

Funding

Vanderbilt Institute for Clinical and Translational Research (VICTR) -Identifying correlates of functional immunity in SARS-CoV-2 convalescent plasmaUL1TR002243 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Paul A. Harris, Wesley H Self · 2017 to 2026
$130.7M
Translational Analysis CoreP30DK058404 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RICHARD M. PEEK · 2002 to 2026
$29.9M
Chemistry-Biology Interface Training GrantT32GM065086 · NIGMS · VANDERBILT UNIVERSITY · PI BACHMANN, BRIAN O, SULIKOWSKI, GARY ALLEN · 2002 to 2022
$7.0M
Chemical Biology of Infectious Diseases (CBID) Training ProgramT32AI112541 · NIAID · VANDERBILT UNIVERSITY · PI Eric P Skaar · 2015 to 2026
$4.0M
Dissecting the role of the coronavirus proofreading exoribonuclease in RNA recombinationF31AI147560 · NIAID · VANDERBILT UNIVERSITY · PI GRIBBLE, JENNIFER · 2020 to 2021
$41k
NCATS NIH HHS UL1 TR002243NIAID NIH HHS F31 AI147560NIAID NIH HHS T32 AI112541NIDDK NIH HHS P30 DK058404NIGMS NIH HHS T32 GM065086
6 · The paper itself

Abstract

For viruses with segmented genomes, genetic diversity is generated by genetic drift, reassortment, and recombination. Recombination produces RNA populations distinct from full-length gene segments and can influence viral population dynamics, persistence, and host immune responses. Viruses in the

Identifiers

PMID33472930
PMCPMC8103698
OpenAlexW3122315515

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.