ArticleNeurology2021
Incidence, Prevalence, and Health Care Outcomes in Idiopathic Intracranial Hypertension: A Population Study.
Article in Neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07191873 (A Phase IV Placebo-controlled Single Center Trial for Tirzepatide in Idiopathic Intracranial Hypertension Trial), which is not on this map. Cited by 52 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Phase IV Placebo-controlled Single Center Trial for Tirzepatide in Idiopathic Intracranial Hypertension Trial (TIIHT)
Open the trial in the graphWho cites it
52 citing papers in PubMed, 1 synthesis or guideline pooled it, 82 citations in OpenAlex.
- Efficacy and Safety of GLP-1 and Dual GIP/GLP-1 Receptor Agonists in Idiopathic Intracranial Hypertension: A Systematic Review and Meta-Analysis.European journal of neurology · 2025Pooled it
- CGRP-provoked headache is associated with a neuroimmune signature in idiopathic intracranial hypertension.The journal of headache and pain · 2026Trial
- Interpretation of increased intracranial pressure findings on brain magnetic resonance imaging in headache patients.Neuroradiology · 2026Article
- Incidence of idiopathic intracranial hypertension (IIH) in adults and children: a 14-year population-based study.Journal of neurology · 2026Article
- Idiopathic ıntracranial hypertension: diagnostic contribution of novel MRI parameters and their relationship with CSF pressure.Acta neurologica Belgica · 2026Article
- Article
- Surgical Interventions in Idiopathic Intracranial Hypertension-A Comprehensive Multi-Center Study of Outcome and the Role of Treatment Indication.European journal of neurology · 2026Observational
- Venous sinus outflow geometry as a predictor of transverse sinus stenting complexity.Neurosurgical review · 2026Article
- Idiopathic Intracranial Hypertension Presenting With Reversible Hemiparesis: A Rare Stroke Mimic.Cureus · 2026Article
- Early brain MRI changes following transvenous embolization of cerebrospinal fluid-venous fistulas in spontaneous intracranial hypotension.Journal of neurointerventional surgery · 2026Article
- "Just lose weight": weight-based medical bias and experiential expertise in intracranial hypertension.Frontiers in psychiatry · 2026Article
- Referral Pattern Changes Over a Decade in a Tertiary Neuro-Ophthalmology Clinic.Clinical ophthalmology (Auckland, N.Z.) · 2026Article
- Multimodal evaluation and etiology-oriented management of chronic intracranial venous hypertension.Frontiers in neurology · 2026Article
- Case Report: Intracranial hypertension occurring in association with subacute thyroiditis.Frontiers in neurology · 2026Article
- Cognitive impairment in idiopathic intracranial hypertension: A conceptual framework and therapeutic implications.Surgical neurology international · 2026Review
- Pulsatile Tinnitus as the Primary Symptom in IIH: A Distinct Clinical Entity.The Laryngoscope · 2025Article
- A Prospective Multicenter Study on the Evaluation of Frequency of Idiopathic Intracranial Hypertension in Korea.Journal of Korean medical science · 2025Observational
- Article
- Idiopathic Intracranial Hypertension in Neonates, Infants, and Toddlers.Journal of clinical medicine · 2025Review
- How can MRI descriptors be optimally combined to predict idiopathic intracranial hypertension?The British journal of radiology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 1 institution in 2 countries.
Funding
Abstract
objectiveTo characterize trends in incidence, prevalence, and health care outcomes in the idiopathic intracranial hypertension (IIH) population in Wales using routinely collected health care data.
methodsWe used and validated primary and secondary care IIH diagnosis codes within the Secure Anonymised Information Linkage databank to ascertain IIH cases and controls in a retrospective cohort study between 2003 and 2017. We recorded body mass index (BMI), deprivation quintile, CSF diversion surgery, and unscheduled hospital admissions in case and control cohorts.
resultsWe analyzed 35 million patient-years of data. There were 1,765 cases of IIH in 2017 (85% female). The prevalence and incidence of IIH in 2017 was 76/100,000 and 7.8/100,000/y, a significant increase from 2003 (corresponding figures = 12/100,000 and 2.3/100,000/y) (
conclusionsIIH incidence and prevalence is increasing considerably, corresponding to population increases in BMI, and is associated with increased deprivation. This has important implications for health care professionals and policy makers given the comorbidities, complications, and increased health care utilization associated with IIH.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.