ArticleJournal of immunology (Baltimore, Md. : 1950)2021
Polyfunctional Tier 2-Neutralizing Antibodies Cloned following HIV-1 Env Macaque Immunization Mirror Native Antibodies in a Human Donor.
David A Spencer, Delphine C Malherbe, Néstor Vázquez Bernat, Monika Ádori, Benjamin Goldberg, Nicholas Dambrauskas, Heidi Henderson, Shilpi Pandey, Tracy Cheever, Philip Barnette and 7 more
Article in Journal of immunology (Baltimore, Md. : 1950), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 33% of its field
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literature
Who cites it
4 citing papers in PubMed, 6 citations in OpenAlex.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
17 authors at 5 institutions in 2 countries.
David A SpencerOregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006.ORCID 0000-0002-5789-6202
Delphine C MalherbeOregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006.
Néstor Vázquez BernatMicrobiology, Tumor and Cell Biology, Karolinska Institutet, 171 65 Solna, Stockholm, Sweden.
Monika ÁdoriMicrobiology, Tumor and Cell Biology, Karolinska Institutet, 171 65 Solna, Stockholm, Sweden.
Benjamin GoldbergThayer School of Engineering, Dartmouth College, Hanover, NH 03755.ORCID 0000-0002-7468-3487
Nicholas DambrauskasCenter for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA 98109.
Heidi HendersonOregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006.
Shilpi PandeyOregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006.
Tracy CheeverOregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006.
Philip BarnetteOregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006.ORCID 0000-0002-8985-6192
William F SuttonOregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006.
Margaret E AckermanThayer School of Engineering, Dartmouth College, Hanover, NH 03755.ORCID 0000-0002-4253-3476
James J KobieInfectious Diseases, School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294.
D Noah SatherCenter for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA 98109.ORCID 0000-0002-9128-172X
Gunilla B Karlsson HedestamMicrobiology, Tumor and Cell Biology, Karolinska Institutet, 171 65 Solna, Stockholm, Sweden.ORCID 0000-0001-7255-9047
Nancy L HaigwoodOregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006.ORCID 0000-0002-1477-9575
Ann J HessellOregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006; hessell@ohsu.edu.ORCID 0000-0001-7471-9366
Oregon National Primate Research Center · USKarolinska Institutet · SECenter for Infectious Disease Research · USDartmouth College · USUniversity of Alabama at Birmingham · US
Funding
Upgrade of confocal microscopy at the Oregon National Primate Research CenterP51OD011092 · OD · OREGON HEALTH & SCIENCE UNIVERSITY · PI Bonnie J. Nagel · 2012 to 2026
$203.9M
Non-Human PrimatesP01AI104722 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI KARLSSON HEDESTAM, GUNILLA · 2014 to 2018
$14.6M
Using monoclonal antibody Fc variants in strategies to eliminate HIV reservoirsR01AI129801 · NIAID · OREGON HEALTH & SCIENCE UNIVERSITY · PI HESSELL, ANN JONES · 2017 to 2021
$4.2M
Targeting tonsillar B cells for the induction of effective mucosal immunity to HIVR01DE027245 · NIDCR · UNIVERSITY OF ROCHESTER · PI KOBIE, JAMES J · 2017 to 2021
Vaccine efforts to combat HIV are challenged by the global diversity of viral strains and shielding of neutralization epitopes on the viral envelope glycoprotein trimer. Even so, the isolation of broadly neutralizing Abs from infected individuals suggests the potential for eliciting protective Abs through vaccination. This study reports a panel of 58 mAbs cloned from a rhesus macaque (
Indexed as
AIDS VaccinesAnimalsAntibodies, MonoclonalAntibodies, NeutralizingBinding SitesCell Lineenv Gene Products, Human Immunodeficiency VirusEpitopesHIV-1HIV AntibodiesHIV InfectionsHumansImmunizationImmunoglobulin Variable RegionMacaca mulattaTHP-1 CellsAIDS VaccinesAntibodies, MonoclonalAntibodies, Neutralizingenv Gene Products, Human Immunodeficiency VirusEpitopesHIV AntibodiesImmunoglobulin Variable RegionViral Envelope Proteins
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Polyfunctional Tier 2-Neutralizing Antibodies Cloned following HIV-1 Env Macaque Immunization Mirror Native Antibodies in a Human Donor. · full record | OpenQuestion