Evidence map›Paper›PMID 33472892›Full record

ArticleCancer research2021

Survivin Expression Is Differentially Regulated by a Selective Cross-talk between RBM38 and miRNAs let-7b or miR-203a.

Christopher A Lucchesi, Jin Zhang, Buyong Ma, Ruth Nussinov, Xinbin Chen

Open access · bronzeAbstract read
In one paragraph

Article in Cancer research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.4field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Christopher A LucchesiComparative Oncology Laboratory, Schools of Veterinary Medicine and Medicine, University of California at Davis, Davis, California.ORCID 0000-0001-8767-7003
Jin ZhangComparative Oncology Laboratory, Schools of Veterinary Medicine and Medicine, University of California at Davis, Davis, California.ORCID 0000-0002-6835-920X
Buyong MaBasic Science Program, Leidos Biomedical Research, Inc., Laboratory of Cancer Immunometabolism, National Cancer Institute, Frederick, Maryland.
Ruth NussinovBasic Science Program, Leidos Biomedical Research, Inc., Laboratory of Cancer Immunometabolism, National Cancer Institute, Frederick, Maryland.
Xinbin ChenComparative Oncology Laboratory, Schools of Veterinary Medicine and Medicine, University of California at Davis, Davis, California. xbchen@ucdavis.edu.ORCID 0000-0002-4582-6506
University of California, Davis · USLeidos (United States) · US

Funding

Protein Structure, Stability, and Amyloid FormationZIABC010440 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI NUSSINOV, RUTH · 2009 to 2025
$11.8M
Biomolecular Recognition and Binding MechanismsZIABC010441 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI NUSSINOV, RUTH · 2009 to 2025
$9.4M
MECHANISM OF P73 DEPENDENT TUMOR SUPPRESSIONR01CA081237 · NCI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CHEN, XINBIN · 1999 to 2022
$6.8M
Training Program in Oncogenic Signals and Chromosome BiologyT32CA108459 · NCI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI HEYER, WOLF-DIETRICH · 2006 to 2020
$3.6M
Mechanism of p53-dependent Tumor SuppressionR01CA250338 · NCI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CHEN, XINBIN · 2020 to 2024
$2.2M
The role of the p63-RBM38 loop in tumor suppressionR01CA195828 · NCI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CHEN, XINBIN · 2016 to 2020
$1.8M
CCR NIH HHS HHSN261200800001CNCI NIH HHS HHSN261200800001ENCI NIH HHS R01 CA081237NCI NIH HHS R01 CA195828NCI NIH HHS R01 CA250338NCI NIH HHS T32 CA108459
6 · The paper itself

Abstract

RNA-binding motif 38 (RBM38) is a member of a protein family with a highly conserved RNA-binding motif and has been shown to regulate mRNA processing, stability, and translation. Survivin is an essential modulator of apoptotic and nonapoptotic cell death as well as a stress responder.

Indexed as

Argonaute ProteinsCell Line, TumorGene Expression Regulation, NeoplasticHCT116 CellsHumansImidazolesMCF-7 CellsMicroRNAsNaphthoquinonesProtein BindingReceptor Cross-TalkRNA-Binding ProteinsRNA StabilitySurvivinAGO2 protein, humanArgonaute ProteinsBIRC5 protein, humanImidazolesMicroRNAsMIRN203 microRNA, humanmirnlet7 microRNA, humanNaphthoquinonesRBM38 protein, humanRNA-Binding ProteinssepantroniumSurvivin

Identifiers

PMID33472892
PMCPMC8137528
OpenAlexW3124851355

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.