Evidence map›Paper›PMID 33472891›Full record

ArticleCancer research2021

The

Yoo Jane Han, Jing Zhang, Jung-Hyun Lee, Jennifer M Mason, Olga Karginova, Toshio F Yoshimatsu, Qinyu Hao, Ian Hurley, Laia Paré Brunet, Aleix Prat and 3 more

Open access · bronzeAbstract read
In one paragraph

Article in Cancer research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.7field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 13 citations in OpenAlex.

  1. BRCA1P1 immunotherapy requires pseudogene-aware transcriptomics.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Reply to Chi et al.: DefiningProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  3. Regulation of antiviral and antitumor immunity by theProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 2 countries.

Yoo Jane HanDepartment of Medicine, Center for Clinical Cancer Genetics and Global Health, University of Chicago, Chicago, Illinois. yjhan@medicine.bsd.uchicago.edu folopade@medicine.bsd.uchicago.edu.
Jing ZhangDepartment of Medicine, Center for Clinical Cancer Genetics and Global Health, University of Chicago, Chicago, Illinois.
Jung-Hyun LeeDepartment of Microbiology, University of Chicago, Chicago, Illinois.
Jennifer M MasonDepartment of Genetics and Biochemistry, Clemson University, Clemson, South Carolina.ORCID 0000-0001-9120-5017
Olga KarginovaDepartment of Medicine, Center for Clinical Cancer Genetics and Global Health, University of Chicago, Chicago, Illinois.
Toshio F YoshimatsuDepartment of Medicine, Center for Clinical Cancer Genetics and Global Health, University of Chicago, Chicago, Illinois.ORCID 0000-0003-2674-8159
Qinyu HaoDepartment of Cell and Developmental Biology, Cancer Center at Illinois, University of Illinois at Urbana-Champaign, Urbana, Illinois.ORCID 0000-0002-7059-7741
Ian HurleyDepartment of Medicine, Center for Clinical Cancer Genetics and Global Health, University of Chicago, Chicago, Illinois.
Laia Paré BrunetTranslational Genomics and Targeted Therapies in Solid Tumors, IDIBAPS, Barcelona, Spain.
Aleix PratTranslational Genomics and Targeted Therapies in Solid Tumors, IDIBAPS, Barcelona, Spain.ORCID 0000-0003-2377-540X
Kannanganattu V PrasanthDepartment of Cell and Developmental Biology, Cancer Center at Illinois, University of Illinois at Urbana-Champaign, Urbana, Illinois.
Michaela U GackDepartment of Microbiology, University of Chicago, Chicago, Illinois.
Olufunmilayo I OlopadeDepartment of Medicine, Center for Clinical Cancer Genetics and Global Health, University of Chicago, Chicago, Illinois. yjhan@medicine.bsd.uchicago.edu folopade@medicine.bsd.uchicago.edu.ORCID 0000-0002-9936-1599
University of Chicago · USBreast Cancer Research Foundation · USUniversity of Illinois Chicago · USUniversity of Illinois Urbana-Champaign · USClemson University · US

Funding

Regulation of Host Innate Immunity Against Viral InfectionR01AI087846 · NIAID · UNIVERSITY OF CHICAGO · PI GACK, MICHAELA ULRIKE · 2010 to 2020
$3.9M
UChicago Interdisciplinary Cancer Health Disparities SPOREP20CA233307 · NCI · UNIVERSITY OF CHICAGO · PI HUO, DEZHENG · 2018 to 2020
$3.4M
Regulation of Host Innate Immunity Against Viral InfectionR37AI087846 · NIAID · CLEVELAND CLINIC LERNER COM-CWRU · PI Michaela Ulrike Gack · 2021 to 2026
$2.8M
Characterization of nuclear-retained RNA-mediated gene regulatory mechanismsR01GM132458 · NIGMS · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI KANNANGANATTU, PRASANTH KUMAR VIJAYAN · 2020 to 2023
$1.4M
Monoalleleic autosomal spreading of a novel family of nucleolus-localized ncRNAsR21AG065748 · NIA · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI KANNANGANATTU, PRASANTH KUMAR VIJAYAN · 2020 to 2021
$423k
NCI NIH HHS P20 CA233307NIAID NIH HHS R01 AI087846NIAID NIH HHS R37 AI087846NIA NIH HHS R21 AG065748NIGMS NIH HHS R01 GM132458
6 · The paper itself

Abstract

Innate immune defense mechanisms play a pivotal role in antitumor responses. Recent evidence suggests that antiviral innate immunity is regulated not only by exogenous non-self-RNA but also by host-derived pseudogene RNAs. A growing body of evidence also indicates a biological role for pseudogenes as gene expression regulators or immune modulators. Here, we report an important role for

Indexed as

AnimalsBreastBreast NeoplasmsCarcinoma, Ductal, BreastCell Line, TumorCell NucleusCytokinesFemaleGene Expression Regulation, NeoplasticGene Knockout TechniquesHost Microbial InteractionsHumansImmunity, InnateMastectomyMicePrimary Cell CultureBRCA1 pseudogene 1, humanCytokinesRELA protein, humanRNA, Long NoncodingTranscription Factor RelA

Identifiers

PMID33472891
PMCPMC7969461
OpenAlexW3121365603

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.