Evidence map›Paper›PMID 33472860›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

Coronavirus replication-transcription complex: Vital and selective NMPylation of a conserved site in nsp9 by the NiRAN-RdRp subunit.

Heiko Slanina, Ramakanth Madhugiri, Ganesh Bylapudi, Karin Schultheiß, Nadja Karl, Anastasia Gulyaeva, Alexander E Gorbalenya, Uwe Linne, John Ziebuhr

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
75citing papers in PubMed, 1 pooled it
16.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

75 citing papers in PubMed, 1 synthesis or guideline pooled it, 129 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. ACS medicinal chemistry letters · 2026
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  5. Article
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  13. Review
  14. SARS-CoV-2 Resistance to Small Molecule Inhibitors.Current clinical microbiology reports · 2024
    Article
  15. Article
  16. Article
  17. SARS-CoV-2 biology and host interactions.Nature reviews. Microbiology · 2024
    Review
  18. Article
  19. Article
  20. Article

15 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

Heiko SlaninaInstitute of Medical Virology, Justus Liebig University Giessen, 35392 Giessen, Germany.ORCID 0000-0001-9642-0023
Ramakanth MadhugiriInstitute of Medical Virology, Justus Liebig University Giessen, 35392 Giessen, Germany.ORCID 0000-0002-9306-4155
Ganesh BylapudiInstitute of Medical Virology, Justus Liebig University Giessen, 35392 Giessen, Germany.ORCID 0000-0003-2657-5585
Karin SchultheißInstitute of Medical Virology, Justus Liebig University Giessen, 35392 Giessen, Germany.
Nadja KarlInstitute of Medical Virology, Justus Liebig University Giessen, 35392 Giessen, Germany.ORCID 0000-0003-1643-9512
Anastasia GulyaevaDepartment of Medical Microbiology, Leiden University Medical Center, Leiden 2300 RC, The Netherlands.ORCID 0000-0002-3587-3587
Alexander E GorbalenyaDepartment of Medical Microbiology, Leiden University Medical Center, Leiden 2300 RC, The Netherlands.ORCID 0000-0002-4967-7341
Uwe LinneMass Spectrometry Facility, Department of Chemistry, Philipps University Marburg, 35043 Marburg, Germany.ORCID 0000-0002-1473-9063
John ZiebuhrInstitute of Medical Virology, Justus Liebig University Giessen, 35392 Giessen, Germany; John.Ziebuhr@viro.med.uni-giessen.de.ORCID 0000-0002-5741-8825
Justus-Liebig-Universität Gießen · DELeiden University Medical Center · NLLomonosov Moscow State University · RUPhilipps University of Marburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

RNA-dependent RNA polymerases (RdRps) of the

Indexed as

Virus ReplicationAmino Acid SequenceAmino Acid SubstitutionAsparagineCell LineConserved SequenceCoronavirus 229E, HumanCoronavirus RNA-Dependent RNA PolymeraseHumansManganeseProtein DomainsRecombinant ProteinsRNA-Binding ProteinsSARS-CoV-2Transcription, GeneticViral Nonstructural ProteinsAsparagineCoronavirus RNA-Dependent RNA PolymeraseManganeseNSP12 protein, SARS-CoV-2ORF1ab polyprotein, SARS-CoV-2Recombinant ProteinsRNA-Binding ProteinsViral Nonstructural ProteinscoronavirusnidovirusNiRANnucleotidyltransferaseRNA polymerase

Identifiers

PMID33472860
PMCPMC8017715
OpenAlexW3124366280

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.