Evidence map›Paper›PMID 33472851›Full record

ReviewDevelopment (Cambridge, England)2021

Dynamic patterning by morphogens illuminated by cis-regulatory studies.

Jihyun Irizarry, Angelike Stathopoulos

Abstract readReview
In one paragraph

Review in Development (Cambridge, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Breaking anterior-posterior symmetry in the moth flybioRxiv : the preprint server for biology · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
    Article
  13. BMP Signaling: Lighting up the Way for Embryonic Dorsoventral Patterning.Frontiers in cell and developmental biology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Jihyun IrizarryCalifornia Institute of Technology, Division of Biology and Biological Engineering, 1200 East California Blvd., Pasadena, CA 91125, USA.
Angelike StathopoulosCalifornia Institute of Technology, Division of Biology and Biological Engineering, 1200 East California Blvd., Pasadena, CA 91125, USA angelike@caltech.edu.ORCID 0000-0001-6597-2036

Funding

Temporal control of cell patterning, signaling, and movement in early embryosR35GM118146 · NIGMS · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI STATHOPOULOS, ANGELIKE · 2016 to 2025
$5.8M
Deciphering when the pivotal transcription factor Dorsal exerts patterning effects using optogeneticsR21HD095639 · NICHD · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI STATHOPOULOS, ANGELIKE · 2018 to 2019
$461k
NICHD NIH HHS R21 HD095639NIGMS NIH HHS R35 GM118146
6 · The paper itself

Abstract

Morphogen concentration changes in space as well as over time during development. However, how these dynamics are interpreted by cells to specify fate is not well understood. Here, we focus on two morphogens: the maternal transcription factors Bicoid and Dorsal, which directly regulate target genes to pattern

Indexed as

AnimalsBody PatterningDrosophila melanogasterDrosophila ProteinsEnhancer Elements, GeneticHumansRegulatory Sequences, Nucleic AcidDrosophila ProteinsActivatorBicoid (Bcd)ChromatinCis-regulatory mechanismDorsal (Dl)Drosophila melanogasterEmbryonic patterningEnhancerGradientMorphogenRepressorThresholds

Identifiers

PMID33472851
PMCPMC7847269

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.