ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2021
Roles of the Default Mode and Multiple-Demand Networks in Naturalistic versus Symbolic Decisions.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 3 of them syntheses that pooled it.
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Who cites it
22 citing papers in PubMed, 3 syntheses or guidelines pooled it, 39 citations in OpenAlex.
- The effect of task complexity on the neural network for response inhibition: An ALE meta-analysis.Neuroscience and biobehavioral reviews · 2024Pooled it
- Non-literal language processing is jointly supported by the language and theory of mind networks: Evidence from a novel meta-analytic fMRI approach.Cortex; a journal devoted to the study of the nervous system and behavior · 2023Pooled it
- Tasks activating the default mode network map multiple functional systems.Brain structure & function · 2022Pooled it
- Domain-general and language-specific brain networks are differentially associated with verbal intelligence during development.iScience · 2026Article
- On the Same Wavelength: The Relationship between Neural Synchrony and Cognitive Ability during Movie Watching in Late Childhood and Early Adolescence.Developmental neuroscience · 2026Article
- Sender-receiver subdivisions of the default mode network in perceptual and memory-guided cognition.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Multimodal neuroimaging of locus coeruleus-default mode network connectivity for predicting dexmedetomidine response in chronic insomnia disorder.Frontiers in psychiatry · 2026Article
- Functions of the posterior cingulate cortex and default network.Current opinion in behavioral sciences · 2025Article
- Contrast Sensitivity Predicts 30-month Functional Brain Network Integrity in Cognitively Unimpaired Older Adults: the Brain Networks and Mobility Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Article
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- Alterations of interhemispheric functional connectivity in patients with hypertensive retinopathy using voxel-mirrored homotopic connectivity: a resting state fMRI study.International journal of ophthalmology · 2025Article
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- Semantic processing in older adults is associated with distributed neural activation which varies by association and abstractness of words.GeroScience · 2024Article
- Dynamic modulation of the processing of unpredicted technical errors by the posterior cingulate and the default mode network.Scientific reports · 2024Article
- Reexamining the Kuleshov effect: Behavioral and neural evidence from authentic film experiments.PloS one · 2024Article
- Article
- External task switches activate default mode regions without enhanced processing of the surrounding scene.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Accounting for temporal variability in functional magnetic resonance imaging improves prediction of intelligence.Human brain mapping · 2023Article
- Situation updating during discourse comprehension recruits right posterior portion of the multiple-demand network.Human brain mapping · 2023Article
- Dynamic subcortical modulators of human default mode network function.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The default mode network (DMN) is often associated with representing semantic, social, and situational content of contexts and episodes. The DMN may therefore be important for contextual decision-making, through representing situational constraints and simulating common courses of events. Most decision-making paradigms, however, use symbolic stimuli and instead implicate cognitive control regions, such as the multiple demand (MD) system. This fMRI study aimed to contrast the brain mechanisms underlying decision-making based on rich naturalistic contexts or symbolic cues. While performing an ongoing task, 40 human participants (25 female) responded to different sounds. For one sound, the stimulus-response mapping was fixed; responses for the other sounds depended on the visual context: either lifelike scenes or letter symbols, varying across participants. Despite minimal behavioral differences between the groups, posterior DMN regions showed increased activity during context-dependent decision-making using the naturalistic scenes only, compared with symbolic cues. More anterior temporal and frontal DMN regions showed a different pattern, with sensitivity to the need for contextual control, but not to the type of context. Furthermore, in the scenes group, widespread DMN regions showed stronger representation of not just the context but also the sound whose significance it modulated. In comparison, the MD system showed strong univariate activity for every decision, but, intriguingly, somewhat reduced activity in the case of a scene-based but demanding context-dependent decision. Depending on context, we suggest, either DMN or MD regions may play a prominent role in selection and control of appropriate behavior.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.