ArticleBMC veterinary research2021
Pathogenicity of novel goose-origin astrovirus causing gout in goslings.
Article in BMC veterinary research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Genomic characterization, recombination analysis and pathogenicity of goose astrovirus 2 isolated from geese in Jiangxi Province, China.Poultry science · 2026Article
- Role of Autophagy in Goose Astrovirus-Induced Renal Injury in Goslings.Animals : an open access journal from MDPI · 2026Article
- Duplex MIRA assays for simultaneous detection of novel goose astrovirus and goose circovirus.BMC veterinary research · 2026Article
- Rapid extraction-free RT-RAA assay for on-site detection of goose astrovirus type 1 in goslings.Frontiers in cellular and infection microbiology · 2026Article
- AGXT-Driven Bile Acid Dysregulation Triggers Viral Gout in Astrovirus-Infected Jiangnan White Geese.Veterinary sciences · 2025Article
- Isolation, Characterization, and Comparative Analysis of Two Subtypes of Goose Astrovirus in Guangdong Province, China.Microorganisms · 2025Article
- Effects and potential pathways of goose astrovirus infection on gosling hepatic lipid metabolism.Frontiers in microbiology · 2025Article
- Screening and identification of protein interacting with goose astrovirus.Frontiers in cellular and infection microbiology · 2025Article
- Progress in modeling avian hyperuricemia and gout (Review).Biomedical reports · 2025Review
- Development of a label-free photoelectrochemical immunosensor for novel astrovirus detection.Mikrochimica acta · 2024Article
- Epidemiological Investigation of Goose Astrovirus in Hebei Province, China, 2019-2021.Microorganisms · 2024Article
- Molecular characterization of a virulent goose astrovirus genotype-2 with high mortality in vitro and in vivo.Poultry science · 2024Article
- Isolation, Identification, and Pathogenicity of a Goose Astrovirus Genotype 1 Strain in Goslings in China.Viruses · 2024Article
- Development of a fast and sensitive RT-qPCR assay based on SYBR® green for diagnostic and quantification of Avian Nephritis Virus (ANV) in chickens affected with enteric disease.BMC veterinary research · 2024Article
- Isolation and Pathogenicity of a Chinese Porcine Astrovirus Type 5 Strain HNPDS-01 and Its Influence on Cecum Microbiota in Piglets.Transboundary and emerging diseases · 2024Article
- Epidemiological investigation and pathogenicity analysis of waterfowl astroviruses in some areas of China.Frontiers in microbiology · 2024Article
- Molecular characteristics and pathogenicity of a novel chicken astrovirus variant.Veterinary research · 2023Article
- Localization and distribution of goose astrovirus 2 antigens in different tissues at different times.BMC veterinary research · 2023Article
- Pathogenicity of goose astrovirus genotype 2 in chickens.Poultry science · 2023Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
backgroundA novel goose-origin astrovirus (GoAstV) has broken out across China in recent years, causing gout in goslings with a mortality rate of around 50%. However, our understanding of the dynamic distribution, tissue tropism and pathogenesis of GoAstV is incomplete. In order to assess its pathogenicity, one-day-old goslings were inoculated separately with GoAstV via oral and subcutaneous injection routes.
resultsClinical symptoms, gross and microscopic lesions, blood biochemical parameters and viral loads were detected and recorded for 20 days after infection. Typical gout was observed in experimental goslings. GoAstV can be replicated in tissues and cause pathological damage, especially in the kidney, liver, heart and spleen. Virus-specific genomic RNA was detected in blood, cloacal swabs and all representative tissues, and virus shedding was detected up to 20 days after inoculation, suggesting that GoAstV has a wide tissue tropism and spread systematically after inoculation. The viral copy numbers examined in kidney were the highest, followed by spleen and liver.
conclusionThis experiment determined the accurate value of viral loads and biochemical indicators of GoAstV-induced goslings. These findings increase our understanding of the pathogenicity of GoAstV in goslings and provide more reference for future research.
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