Evidence map›Paper›PMID 33472580›Full record

ReviewCellular & molecular biology letters2021

Mesenchymal stem cells as a double-edged sword in tumor growth: focusing on MSC-derived cytokines.

Wenqing Liang, Xiaozhen Chen, Songou Zhang, Jian Fang, Meikai Chen, Yifan Xu, Xuerong Chen

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cellular & molecular biology letters, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 114 papers.

0numbers the graph read from it
0cells of the map it votes in
114citing papers in PubMed
21.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

114 citing papers in PubMed, 183 citations in OpenAlex.

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54 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Wenqing Liang *Department of Orthopaedics, Zhoushan Hospital of Traditional Chinese Medicine Affiliated to Zhejiang Chinese Medical University, 355 Xinqiao Road, Dinghai District, Zhoushan, 316000, Zhejiang, People's Republic of China. drliangwenqing@yeah.net.ORCID http://orcid.org/0000-0001-9770-882X
Xiaozhen Chen *College of Medicine, Shaoxing University, Shaoxing, 312000, Zhejiang, People's Republic of China.
Songou Zhang *College of Medicine, Shaoxing University, Shaoxing, 312000, Zhejiang, People's Republic of China.
Jian FangCollege of Medicine, Shaoxing University, Shaoxing, 312000, Zhejiang, People's Republic of China.
Meikai ChenDepartment of Orthopaedics, Shaoxing People's Hospital, The First Affiliated Hospital of Shaoxing University, Shaoxing, 312000, Zhejiang, People's Republic of China.
Yifan XuDepartment of Orthopaedics, Shaoxing People's Hospital, The First Affiliated Hospital of Shaoxing University, Shaoxing, 312000, Zhejiang, People's Republic of China.
Xuerong ChenDepartment of Orthopaedics, Shaoxing People's Hospital, The First Affiliated Hospital of Shaoxing University, Shaoxing, 312000, Zhejiang, People's Republic of China.
Shaoxing University · CNZhejiang Chinese Medical University · CN

Funding

Fundamental Research Program of Public Good in Zhejiang Province LGF18H060006Fundamental Research Program of Public Good in Zhejiang Province LGF20H060010Nature Science Foundation of Zhejiang Province LY18H060013
6 · The paper itself

Abstract

Mesenchymal stem cells (MSCs) show homing capacity towards tumor sites. Numerous reports indicate that they are involved in multiple tumor-promoting processes through several mechanisms, including immunosuppression; stimulation of angiogenesis; transition to cancer-associated fibroblasts; inhibition of cancer cell apoptosis; induction of epithelial-mesenchymal transition (EMT); and increase metastasis and chemoresistance. However, other studies have shown that MSCs suppress tumor growth by suppressing angiogenesis, incrementing inflammatory infiltration, apoptosis and cell cycle arrest, and inhibiting the AKT and Wnt signaling pathways. In this review, we discuss the supportive and suppressive impacts of MSCs on tumor progression and metastasis. We also discuss MSC-based therapeutic strategies for cancer based on their potential for homing to tumor sites.

Indexed as

AnimalsApoptosisCytokinesHumansImmunityMesenchymal Stem CellsNeoplasmsTumor MicroenvironmentCytokinesAngiogenesisCancer-associated fibroblastsImmunosuppressionMesenchymal stem cellsMetastasis

Identifiers

PMID33472580
PMCPMC7818947
OpenAlexW3125219489

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.