ArticleMolecular medicine (Cambridge, Mass.)2021
The transcriptome-wide association search for genes and genetic variants which associate with BMI and gestational weight gain in women with type 1 diabetes.
Article in Molecular medicine (Cambridge, Mass.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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5 citing papers in PubMed, 6 citations in OpenAlex.
- Role ofInternational journal of molecular sciences · 2026Article
- Polygenic risk score as a tool to predict gestational weight gain and gestational diabetes among pregnant women in Taiwan.Journal of human genetics · 2025Article
- Gestational Weight Gain: Is the Role of Genetic Variants a Determinant? A Review.International journal of molecular sciences · 2024Review
- A study to investigate genetic factors associated with weight gain in people with diabetes: analysis of polymorphisms in four relevant genes.Adipocyte · 2023Article
- Review
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Authors and funding
11 authors at 3 institutions in 2 countries.
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Abstract
backgroundClinical data suggest that BMI and gestational weight gain (GWG) are strongly interconnected phenotypes; however, the genetic basis of the latter is rather unclear. Here we aim to find genes and genetic variants which influence BMI and/or GWG.
methodsWe have genotyped 316 type 1 diabetics using Illumina Infinium Omni Express Exome-8 v1.4 arrays. The GIANT, ARIC and T2D-GENES summary statistics were used for TWAS (performed with PrediXcan) in adipose tissue. Next, the analysis of association of imputed expression with BMI in the general and diabetic cohorts (Analysis 1 and 2) or GWG (Analysis 3 and 4) was performed, followed by variant association analysis (1 Mb around identified loci) with the mentioned phenotypes.
resultsIn Analysis 1 we have found 175 BMI associated genes and 19 variants (p < 10
conclusionsHere, we have shown that loci influencing BMI might have an impact on GWG and GWG associated loci might influence BMI, both in the general and T1DM cohorts. The results suggest that both phenotypes are related to insulin signaling, glucose homeostasis, mitochondrial metabolism, ubiquitinoylation and inflammatory responses.
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