Evidence map›Paper›PMID 33472400›Full record

ArticleArteriosclerosis, thrombosis, and vascular biology2021

Statin Effects on Vascular Calcification: Microarchitectural Changes in Aortic Calcium Deposits in Aged Hyperlipidemic Mice.

Joshua Zhaojun Xian, Mimi Lu, Felicia Fong, Rong Qiao, Nikhil Rajesh Patel, Dishan Abeydeera, Sidney Iriana, Linda L Demer, Yin Tintut

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Arteriosclerosis, thrombosis, and vascular biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
6.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 39 citations in OpenAlex.

  1. Article
  2. Article
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  5. medRxiv : the preprint server for health sciences · 2025
    Article
  6. Review
  7. Rosuvastatin Is Associated With Incidental Dermal Calcification.The American Journal of dermatopathology · 2025
    Article
  8. Article
  9. Frontiers in cardiovascular medicine · 2025
    Article
  10. Review
  11. Article
  12. Article
  13. Review
  14. Article
  15. Review
  16. Machine-Learning Assessed Abdominal Aortic Calcification is Associated with Long-Term Fall and Fracture Risk in Community-Dwelling Older Australian Women.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2023
    Article
  17. Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 3 countries.

Joshua Zhaojun XianDepartment of Medicine (J.Z.X., M.L., F.F., R.Q., N.R.P., D.A., S.I., L.L.D., Y.T.), University of California, Los Angeles.
Mimi LuDepartment of Medicine (J.Z.X., M.L., F.F., R.Q., N.R.P., D.A., S.I., L.L.D., Y.T.), University of California, Los Angeles.
Felicia FongDepartment of Medicine (J.Z.X., M.L., F.F., R.Q., N.R.P., D.A., S.I., L.L.D., Y.T.), University of California, Los Angeles.
Rong QiaoDepartment of Medicine (J.Z.X., M.L., F.F., R.Q., N.R.P., D.A., S.I., L.L.D., Y.T.), University of California, Los Angeles.
Nikhil Rajesh PatelDepartment of Medicine (J.Z.X., M.L., F.F., R.Q., N.R.P., D.A., S.I., L.L.D., Y.T.), University of California, Los Angeles.
Dishan AbeydeeraDepartment of Medicine (J.Z.X., M.L., F.F., R.Q., N.R.P., D.A., S.I., L.L.D., Y.T.), University of California, Los Angeles.
Sidney IrianaDepartment of Medicine (J.Z.X., M.L., F.F., R.Q., N.R.P., D.A., S.I., L.L.D., Y.T.), University of California, Los Angeles.
Linda L DemerDepartment of Medicine (J.Z.X., M.L., F.F., R.Q., N.R.P., D.A., S.I., L.L.D., Y.T.), University of California, Los Angeles.
Yin TintutDepartment of Medicine (J.Z.X., M.L., F.F., R.Q., N.R.P., D.A., S.I., L.L.D., Y.T.), University of California, Los Angeles.
University of California, Los Angeles · USUniversity of Kentucky · US

Funding

Serotonin receptor contribution to inflammation-induced calcific aortic valve diseaseR01HL137647 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DEMER, LINDA L., TINTUT, YIN · 2019 to 2022
$1.6M
Does aging transform calcific vasculopathy into a plaque stabilizing process?R21AG061586 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DEMER, LINDA L., TINTUT, YIN · 2019 to 2020
$429k
NHLBI NIH HHS R01 HL137647NIA NIH HHS R21 AG061586
6 · The paper itself

Abstract

[Figure: see text].

Indexed as

Age FactorsAnimalsAortaAortic DiseasesAtherosclerosisCalciumDisease Models, AnimalFemaleHydroxymethylglutaryl-CoA Reductase InhibitorsHyperlipidemiasLipidsMiceMice, Inbred C57BLMice, Knockout, ApoEPlaque, AtheroscleroticPravastatinCalciumHydroxymethylglutaryl-CoA Reductase InhibitorsLipidsPravastatinagingarteryatherosclerosispositron emission tomographypravastatinvascularvascular calcification

Identifiers

PMID33472400
PMCPMC7990692
OpenAlexW3122395671

What OpenQuestion holds

Texttitle and abstract
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.