ArticleThe American journal of psychiatry2021
Association of Neural Reward Circuitry Function With Response to Psychotherapy in Youths With Anxiety Disorders.
Article in The American journal of psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 3 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 3 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- Examining the relationship between pre-treatment anhedonia and treatment outcomes in individuals with anxiety or depression: A systematic review.Journal of affective disorders · 2026Pooled it
- Alterations in resting-state brain activity patterns following antidepressant treatment: insights from a coordinate-based meta-analysis.Psychological medicine · 2025Pooled it
- The effects of Lysergic Acid Diethylamide (LSD) on the Positive Valence Systems: A Research Domain Criteria (RDoC)-Informed Systematic Review.CNS drugs · 2023Pooled it
- The role of reward-related brain activity in response to treatment and later depression severity: data from a randomized controlled trial in early adolescents with anxiety disorders.Translational psychiatry · 2025Trial
- Prediction of generalized anxiety disorder treatment outcomes with neurobehavioral responses to approach-avoidance conflict: a randomized clinical trial.Translational psychiatry · 2025Trial
- Amplification of positivity for depression and anxiety: Neural prediction of treatment response.Behaviour research and therapy · 2024Trial
- More time awake after sleep onset is linked to reduced ventral striatum response to rewards in youth with anxiety.Journal of child psychology and psychiatry, and allied disciplines · 2023Trial
- Reward Sensitivity Predicts the Response to Cognitive Behavioral Therapy for Children with Autism and Anxiety.Journal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53Trial
- Oxytocin as a Biomarker of Differential Effects to SPACE vs. CBT Treatment of Child Anxiety Disorders.Journal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53Trial
- Functional connectivity during positive mood and anxiety treatment response in children.Journal of affective disorders · 2026Article
- Structural brain differences associated with panic disorder: an ENIGMA-Anxiety Working Group mega-analysis of 4924 individuals worldwide.Molecular psychiatry · 2026Article
- Social closeness and reward sensitivity enhance corticostriatal function during experiences of shared rewards.Biological psychology · 2026Article
- Reward processing differences in autism: current understandings and future directions.Social cognitive and affective neuroscience · 2026Review
- Reward processing disruption in anxiety: fMRI evidence of vulnerability to frustration non-reward.Psychological medicine · 2025Article
- Social Closeness and Reward Sensitivity Enhance Corticostriatal Function during Experiences of Shared Rewards.bioRxiv : the preprint server for biology · 2025Article
- Neuroimaging and Emotional Development in the Pediatric Population: Understanding the Link Between the Brain, Emotions, and Behavior.Pediatric reports · 2025Review
- Pretreatment anhedonia as a predictor of exposure-based anxiety treatment outcomes.Journal of psychiatric research · 2025Article
- Neural activity to reward and loss predicting treatment outcomes for adults with generalized anxiety disorder: A randomized clinical trial.Journal of mood and anxiety disorders · 2025Article
- Integration of valence and conflict processing through cellular-field interactions in human subgenual cingulate during emotional face processing in treatment-resistant depression.Molecular psychiatry · 2025Article
- Neural Markers of Treatment Response in Pediatric Anxiety and PTSD.Current topics in behavioral neurosciences · 2025Review
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
objectiveIdentifying neural correlates of response to psychological treatment may inform targets for interventions designed to treat psychiatric disorders. This study examined the extent to which baseline functioning in reward circuitry is associated with response to psychotherapy in youths with anxiety disorders.
methodsA randomized clinical trial of cognitive-behavioral therapy compared with supportive therapy was conducted in youths with anxiety disorders. Before treatment, 72 youths (9-14 years old) with anxiety disorders and 37 group-matched healthy comparison youths completed a monetary reward functional MRI task. Treatment response was defined categorically as at least a 35% reduction in diagnostician-rated anxiety severity from pre- to posttreatment assessment. Pretreatment neural activation in the striatum and medial prefrontal cortex (mPFC) during monetary wins relative to losses was examined in relation to treatment response.
resultsResponders, nonresponders, and healthy youths differed significantly in mPFC activation to rewards versus losses at baseline. Youths with anxiety exhibited higher mPFC activity relative to healthy youths, although this may have been driven by differences in depressive symptoms. Planned comparisons between treatment responders (N=48) and nonresponders (N=24) also revealed greater pretreatment neural activation in a cluster encompassing the subgenual anterior cingulate cortex and nucleus accumbens among responders.
conclusionsStriatal activation to reward receipt may not differentiate youths with anxiety from healthy youths. However, higher striatal responsivity to rewards may allow youths with anxiety to improve during treatment, potentially through greater engagement in therapy. Function in reward circuitry may guide development of treatments for youths with anxiety.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.