ArticleNature2021
NINJ1 mediates plasma membrane rupture during lytic cell death.
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In one paragraph
Article in Nature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 506 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
506citing papers in PubMed, 1 pooled it
115.1field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
506 citing papers in PubMed, 1 synthesis or guideline pooled it, 759 citations in OpenAlex.
- xCT (Slc7a11) Regulation: Lessons from Cancer Research.Neurochemical research · 2026Pooled it
- Mechanotransduction by nuclear envelope tension.Nucleus (Austin, Tex.) · 2026Review
- NINJ1-mediated membrane rupture bridges cell death to tissue inflammation.Biochemical Society transactions · 2026Review
- Role of PANoptosis in cancer: molecular mechanisms and therapeutic insights.Archives of toxicology · 2026Review
- Mechanistic insights and therapeutic implications of mitoxyperilysis: a spatially gated mitochondria-dependent lytic cell death.Apoptosis : an international journal on programmed cell death · 2026Review
- A Novel Biofilm Amyloid Ligand for Caspase-11 Drives Hyperactivation in Dendritic Cells.bioRxiv : the preprint server for biology · 2026Article
- The gasdermin family: from pyroptosis mechanisms to therapeutic targets.Signal transduction and targeted therapy · 2026Review
- Igniting antitumour immunity with cancer cell pyroptosis.Nature reviews. Cancer · 2026Review
- Comparative insights into the apoptosome, inflammasomes and PIDDosome.Nature reviews. Immunology · 2026Review
- The NLRP3 inflammasome at the crossroads of innate immune signaling and cell death.Cellular & molecular immunology · 2026Review
- NINJ1: implications for plasma membrane rupture and disease.Biochemical Society transactions · 2026Review
- Nerve injury-induced protein 2 preserves lysosomal membrane integrity to suppress ferroptosis.eLife · 2026Article
- Pyroptotic cell-derived factors promote osteoclast differentiation.bioRxiv : the preprint server for biology · 2026Article
- Mechanisms underlying propagation of ferroptotic cell death.Nature cell biology · 2026Review
- Bile Acid Glycochenodeoxycholic Acid (GCDCA) Might Induce the Loss of Plasma Membrane Integrity and the Release of LDH From Ovarian Granulosa Cells, With Implications in PCOS.Journal of applied toxicology : JAT · 2026Article
- Ninjurin-1 mediates hepatic ischemia-reperfusion injury.Science advances · 2026Article
- Immune Targeting of Oligomeric Ninjurin 1 Protects Against Myocardial Infarction in Mice.Circulation research · 2026Article
- Mechanism and plasticity of primitive pyroptosis.Science advances · 2026Article
- Structural and molecular principles of DAMP biology.Nature structural & molecular biology · 2026Review
- Advances in targeting IL-1 family cytokines for the treatment of inflammatory diseases.Nature reviews. Rheumatology · 2026Review
446 more citing papers are in PubMed but not listed here.
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Authors and funding
27 authors at 4 institutions in 3 countries.
Nobuhiko KayagakiDepartment of Physiological Chemistry, Genentech Inc., South San Francisco, CA, USA. kayagaki@gene.com.ORCID http://orcid.org/0000-0001-8129-1740
Opher S KornfeldDepartment of Physiological Chemistry, Genentech Inc., South San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-4795-6574
Bettina L LeeDepartment of Physiological Chemistry, Genentech Inc., South San Francisco, CA, USA.
Irma B StoweDepartment of Physiological Chemistry, Genentech Inc., South San Francisco, CA, USA.
Karen O'RourkeDepartment of Physiological Chemistry, Genentech Inc., South San Francisco, CA, USA.
Qingling LiDepartment of Microchemistry, Proteomics and Lipidomics, Genentech Inc., South San Francisco, CA, USA.
Wendy SandovalDepartment of Microchemistry, Proteomics and Lipidomics, Genentech Inc., South San Francisco, CA, USA.
Donghong YanDepartment of Translational Immunology, Genentech Inc., South San Francisco, CA, USA.
Jing KangDepartment of Translational Immunology, Genentech Inc., South San Francisco, CA, USA.
Min XuDepartment of Translational Immunology, Genentech Inc., South San Francisco, CA, USA.
Juan ZhangDepartment of Translational Immunology, Genentech Inc., South San Francisco, CA, USA.
Wyne P LeeDepartment of Translational Immunology, Genentech Inc., South San Francisco, CA, USA.
Brent S McKenzieDepartment of Translational Immunology, Genentech Inc., South San Francisco, CA, USA.
Gözde UlasDepartment of Biochemical and Cellular Pharmacology, Genentech Inc., South San Francisco, CA, USA.
Jian PayandehDepartment of Structural Biology, Genentech Inc., South San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-4015-9716
Merone Roose-GirmaDepartment of Molecular Biology, Genentech Inc., South San Francisco, CA, USA.
Zora ModrusanDepartment of Microchemistry, Proteomics and Lipidomics, Genentech Inc., South San Francisco, CA, USA.
Rohit RejaDepartment of Bioinformatics, Genentech Inc., South San Francisco, CA, USA.
Meredith SagollaDepartment of Pathology, Genentech Inc., South San Francisco, CA, USA.
Joshua D WebsterDepartment of Pathology, Genentech Inc., South San Francisco, CA, USA.
Vicky ChoThe Australian Phenomics Facility, The John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory, Australia.ORCID http://orcid.org/0000-0001-9039-9876
T Daniel AndrewsDepartment of Immunology and Infectious Diseases, The John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory, Australia.
Lucy X MorrisThe Australian Phenomics Facility, The John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory, Australia.
Lisa A MiosgeThe Australian Phenomics Facility, The John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory, Australia.
Christopher C GoodnowGarvan Institute of Medical Research, Sydney, New South Wales, Australia.ORCID http://orcid.org/0000-0001-5296-6155
Edward M BertramThe Australian Phenomics Facility, The John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory, Australia.
Vishva M DixitDepartment of Physiological Chemistry, Genentech Inc., South San Francisco, CA, USA. dixit@gene.com.ORCID http://orcid.org/0000-0001-6983-0326
Australian National University · AUGarvan Institute of Medical Research · AUGenesys (United States) · USGene Therapy Laboratory · FR
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plasma membrane rupture (PMR) is the final cataclysmic event in lytic cell death. PMR releases intracellular molecules known as damage-associated molecular patterns (DAMPs) that propagate the inflammatory response
Indexed as
Cell DeathAnimalsApoptosisCell Adhesion Molecules, NeuronalCell MembraneFemaleHumansMacrophagesMaleMiceMutationNecrosisNerve Growth FactorsProtein MultimerizationPyroptosisCell Adhesion Molecules, NeuronalNerve Growth FactorsNINJ1 protein, humanNinj1 protein, mouse
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.