Evidence map›Paper›PMID 33472189›Full record

ArticlePhysics in medicine and biology2021

Abbreviated on-treatment CBCT using roughness penalized mono-energization of kV-MV data and a multi-layer MV imager.

Matthew W Jacobson, Mathias Lehmann, Pascal Huber, Adam Wang, Marios Myronakis, Mengying Shi, Dianne Ferguson, Ingrid Valencia-Lozano, Yue-Houng Hu, Paul Baturin and 5 more

Abstract read
In one paragraph

Article in Physics in medicine and biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Matthew W JacobsonDepartment of Radiation Oncology, Brigham and Women's Hospital, Dana-Farber Cancer Institute, and Harvard Medical School, Boston, MA, 02115, United States of America.ORCID 0000-0001-7616-945X
Mathias LehmannVarian Medical Systems, Baden-Dattwil, CH-5405, Switzerland.
Pascal HuberVarian Medical Systems, Baden-Dattwil, CH-5405, Switzerland.
Adam WangVarian Medical Systems, Palo Alto, CA, 94304-1030, United States of America.
Marios MyronakisDepartment of Radiation Oncology, Brigham and Women's Hospital, Dana-Farber Cancer Institute, and Harvard Medical School, Boston, MA, 02115, United States of America.
Mengying ShiMedical Physics Program, Department of Physics and Applied Physics, University of Massachusetts Lowell, Lowell, MA 01854, United States of America.
Dianne FergusonDepartment of Radiation Oncology, Brigham and Women's Hospital, Dana-Farber Cancer Institute, and Harvard Medical School, Boston, MA, 02115, United States of America.
Ingrid Valencia-LozanoDepartment of Radiation Oncology, Brigham and Women's Hospital, Dana-Farber Cancer Institute, and Harvard Medical School, Boston, MA, 02115, United States of America.ORCID 0000-0002-9130-8590
Yue-Houng HuDepartment of Radiation Oncology, Brigham and Women's Hospital, Dana-Farber Cancer Institute, and Harvard Medical School, Boston, MA, 02115, United States of America.
Paul BaturinVarian Medical Systems, Palo Alto, CA, 94304-1030, United States of America.
Tom HarrisDepartment of Radiation Oncology, Brigham and Women's Hospital, Dana-Farber Cancer Institute, and Harvard Medical School, Boston, MA, 02115, United States of America.
Rony FueglistallerVarian Medical Systems, Baden-Dattwil, CH-5405, Switzerland.
Christopher WilliamsDepartment of Radiation Oncology, Brigham and Women's Hospital, Dana-Farber Cancer Institute, and Harvard Medical School, Boston, MA, 02115, United States of America.
Daniel MorfVarian Medical Systems, Baden-Dattwil, CH-5405, Switzerland.
Ross BerbecoDepartment of Radiation Oncology, Brigham and Women's Hospital, Dana-Farber Cancer Institute, and Harvard Medical School, Boston, MA, 02115, United States of America.

Funding

A novel flat-panel detector for advanced on-board radiation therapy imagingR01CA188446 · NCI · DANA-FARBER CANCER INST · PI BERBECO, ROSS I., FUEGLISTALLER, RONY · 2014 to 2024
$7.2M
NCI NIH HHS R01 CA188446
6 · The paper itself

Abstract

Simultaneous acquisition of cone beam CT (CBCT) projections using both the kV and MV imagers of an image guided radiotherapy system reduces set-up scan times-a benefit to lung cancer radiation oncology patients-but increases noise in the 3D reconstruction. In this article, we present a kV-MV scan time reduction technique that uses two noise-reducing measures to achieve superior performance. The first is a high-DQE multi-layer MV imager prototype. The second is a beam hardening correction algorithm which combines poly-energetic modeling with edge-preserving, regularized smoothing of the projections. Performance was tested in real acquisitions of the Catphan 604 and a thorax phantom. Percent noise was quantified from voxel values in a soft tissue volume of interest (VOI) while edge blur was quantified from a VOI straddling a boundary between air and soft material. Comparisons in noise/resolution performance trade-off were made between our proposed approach, a dose-equivalent kV-only scan, and a kV-MV reconstruction technique previously published by Yin

Indexed as

Radiotherapy, Image-GuidedSpiral Cone-Beam Computed TomographyCone-Beam Computed TomographyHumansParticle AcceleratorsPhantoms, Imagingcone beam CTkV‐MVpoly-energeticradiation therapyradiotherapyscan time reduction

Identifiers

PMID33472189
PMCPMC11103584

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.