Evidence map›Paper›PMID 33472115›Full record

ArticleFungal genetics and biology : FG & B2021

The spindle pole-body localization of activated cytoplasmic dynein is cell cycle-dependent in Aspergillus nidulans.

Baronger Dowell Bieger, Aysha H Osmani, Xin Xiang, Martin J Egan

Open access · greenAbstract read
In one paragraph

Article in Fungal genetics and biology : FG & B, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. VezA/vezatin facilitates proper assembly of the dynactin complex in vivo.bioRxiv : the preprint server for biology · 2024
    Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Baronger Dowell BiegerDepartment of Entomology and Plant Pathology, University of Arkansas Systems Division of Agriculture, Fayetteville, AR, USA.
Aysha H OsmaniDepartment of Molecular Genetics, The Ohio State University, Columbus, OH, USA.
Xin XiangDepartment of Biochemistry and Molecular Biology, the Uniformed Services University - F. Edward Hébert School of Medicine, Bethesda, MD, USA. Electronic address: xin.xiang@usuhs.edu.
Martin J EganDepartment of Entomology and Plant Pathology, University of Arkansas Systems Division of Agriculture, Fayetteville, AR, USA. Electronic address: me021@uark.edu.
University of Arkansas System · USThe Ohio State University · USUniformed Services University of the Health Sciences · US

Funding

Regulation of cytoplasmic dynein in vivoR01GM121850 · NIGMS · HENRY M. JACKSON FDN FOR THE ADV MIL/MED · PI XIANG, XIN · 2017 to 2020
$1.2M
Understanding the mechanisms of spatial protein quality control in a model filamentous fungusR15GM132869 · NIGMS · UNIVERSITY OF ARKANSAS AT FAYETTEVILLE · PI EGAN, MARTIN JOHN · 2019 to 2019
$427k
NIGMS NIH HHS R01 GM121850NIGMS NIH HHS R15 GM132869
6 · The paper itself

Abstract

Cytoplasmic dynein is a minus end-directed microtubule motor that can be activated by cargo adapters. In Aspergillus nidulans, overexpression of ΔC-HookA, the early endosomal adapter HookA missing its cargo-binding site, causes activated dynein to accumulate at septa and spindle pole bodies (SPBs) where the microtubule-organizing centers are located. Intriguingly, only some interphase nuclei show SPB signals of dynein. Here we present data demonstrating that localization of the activated dynein at SPBs is cell cycle-dependent: SPB dynein signals are seen to associate with nuclei at early G1 but disappear at about the G1-S boundary.

Indexed as

Cell CycleAspergillus nidulansBinding SitesCytoplasmic DyneinsProtein BindingProtein TransportSpindle PolesCytoplasmic DyneinsAspergillus nidulansDyneinSpindle-pole body

Identifiers

PMID33472115
PMCPMC7889732
OpenAlexW3122740706

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.