Evidence map›Paper›PMID 33471940›Full record

ReviewWound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society2021

Reactive oxygen species during heart regeneration in zebrafish: Lessons for future clinical therapies.

Olivia Helston, Enrique Amaya

Open access · hybridAbstract readReview
In one paragraph

Review in Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Mammalian organ regeneration in spiny mice.Journal of muscle research and cell motility · 2023
    Review
  4. Review
  5. Metabolic Regulation of Cardiac Regeneration.Frontiers in cardiovascular medicine · 2022
    Review
  6. Reactive oxygen species during heart regeneration in zebrafish: Lessons for future clinical therapies.Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Olivia HelstonDivision of Cell Matrix Biology and Regenerative Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
Enrique AmayaDivision of Cell Matrix Biology and Regenerative Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.ORCID 0000-0002-1805-8548
Wellcome Centre for Cell-Matrix Research · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In humans, myocardial infarction (MI) is associated with irreversible damage to heart tissue, resulting in increased morbidity and mortality in patients. By comparison, the zebrafish (Danio rerio) is capable of repairing damaged and injured hearts by activating a full regenerative response. By studying model organisms that can regenerate loss heart tissue following injury, such as the zebrafish, a greater insight will be gained into the molecular pathways that can induce and sustain a regenerative response following injury. There is hope that such information may lead to new treatments or therapies aimed at stimulating a better regenerative response in humans that have suffered heart attacks. Recent findings in zebrafish have highlighted an important role for sustained elevated levels of Reactive Oxygen Species (ROS), including hydrogen peroxide (H

Indexed as

Wound HealingZebrafishAnimalsHeartHumansMyocytes, CardiacReactive Oxygen SpeciesRegenerationReactive Oxygen Species

Identifiers

PMID33471940
PMCPMC8611801
OpenAlexW3122612492

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.