ArticlePloS one2021
In silico comparative genomics of SARS-CoV-2 to determine the source and diversity of the pathogen in Bangladesh.
Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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21 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- The D614G Virus Mutation Enhances Anosmia in COVID-19 Patients: Evidence from a Systematic Review and Meta-analysis of Studies from South Asia.ACS chemical neuroscience · 2021Pooled it
- Genomic epidemiology of early SARS-CoV-2 transmission dynamics in Bangladesh.Virology journal · 2024Article
- Phylo-geo haplotype network-based characterization of SARS-CoV-2 strains circulating in India (2020-2022).The Indian journal of medical research · 2024Article
- Evolution of Sequence and Structure of SARS-CoV-2 Spike Protein: A Dynamic Perspective.ACS omega · 2023Review
- Omicron SARS-CoV-2 Variants in anPolish journal of microbiology · 2022Article
- Data capture and sharing in the COVID-19 pandemic: a cause for concern.The Lancet. Digital health · 2022Review
- Transmission Dynamics and Genomic Epidemiology of Emerging Variants of SARS-CoV-2 in Bangladesh.Tropical medicine and infectious disease · 2022Article
- Cross-sectional genomic perspective of epidemic waves of SARS-CoV-2: A pan India study.Virus research · 2022Article
- Genomic Surveillance of COVID-19 Variants With Language Models and Machine Learning.Frontiers in genetics · 2022Article
- Genomic surveillance unfolds the SARS-CoV-2 transmission and divergence dynamics in Bangladesh.Frontiers in genetics · 2022Article
- Characterization and Structural Prediction of Proteins in SARS-CoV-2 Bangladeshi Variant Through Bioinformatics.Microbiology insights · 2022Article
- Characterization of altered genomic landscape of SARS-CoV-2 variants isolated in Saudi Arabia in a comparativeSaudi journal of biological sciences · 2021Article
- Investigating the possible origin and transmission routes of SARS-CoV-2 genomes and variants of concern in Bangladesh.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2021Article
- The Evolutionary Landscape of SARS-CoV-2 Variant B.1.1.519 and Its Clinical Impact in Mexico City.Viruses · 2021Article
- Temporal landscape of mutational frequencies in SARS-CoV-2 genomes of Bangladesh: possible implications from the ongoing outbreak in Bangladesh.Virus genes · 2021Article
- Article
- Designing potential siRNA molecule for the nucleocapsid(N) gene silencing of different SARS-CoV-2 strains of Bangladesh: Computational approach.Computational biology and chemistry · 2021Article
- Molecular Analysis of SARS-CoV-2 Circulating in Bangladesh during 2020 Revealed Lineage Diversity and Potential Mutations.Microorganisms · 2021Article
- Global and local mutations in Bangladeshi SARS-CoV-2 genomes.Virus research · 2021Article
- Extensive genetic diversity with novel mutations in spike glycoprotein of severe acute respiratory syndrome coronavirus 2, Bangladesh in late 2020.New microbes and new infections · 2021Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The COVID19 pandemic caused by SARS-CoV-2 virus has severely affected most countries of the world including Bangladesh. We conducted comparative analysis of publicly available whole-genome sequences of 64 SARS-CoV-2 isolates in Bangladesh and 371 isolates from another 27 countries to predict possible transmission routes of COVID19 to Bangladesh and genomic variations among the viruses. Phylogenetic analysis indicated that the pathogen was imported in Bangladesh from multiple countries. The viruses found in the southern district of Chattogram were closely related to strains from Saudi Arabia whereas those in Dhaka were similar to that of United Kingdom and France. The 64 SARS-CoV-2 sequences from Bangladesh belonged to three clusters. Compared to the ancestral SARS-CoV-2 sequence reported from China, the isolates in Bangladesh had a total of 180 mutations in the coding region of the genome, and 110 of these were missense. Among these, 99 missense mutations (90%) were predicted to destabilize protein structures. Remarkably, a mutation that leads to an I300F change in the nsp2 protein and a mutation leading to D614G change in the spike protein were prevalent in SARS-CoV-2 genomic sequences, and might have influenced the epidemiological properties of the virus in Bangladesh.
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