ArticlePloS one2021
Clinical characteristics of treatment-resistant depression in adults in Hungary: Real-world evidence from a 7-year-long retrospective data analysis.
Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Pooled it
- Examining the needs, outcomes and current treatment pathways of 2461 people with treatment-resistant depression: mixed-methods study.The British journal of psychiatry : the journal of mental science · 2026Article
- Evaluating the effectiveness of the "Spine Up" online program on depression and quality of life in people with multiple sclerosis: a pilot test for a 16-week intervention.Frontiers in sports and active living · 2026Article
- All-cause and cause-specific mortality in people with depression: a large-scale systematic review and meta-analysis of relative risk and aggravating or attenuating factors, including antidepressant treatment.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2025Article
- Mechanisms Underlying Treatment-Resistant Depression: Exploring Sex-Based Biological Differences.Journal of neurochemistry · 2025Review
- [Long-term courses of major depressive disorder : Characteristics, risk factors and the definitional challenge of treatment response].Der Nervenarzt · 2025Review
- Trends in research on novel antidepressant treatments.Frontiers in pharmacology · 2025Review
- Mortality in patients with major depressive disorder: A nationwide population-based cohort study with 11-year follow-up.European psychiatry : the journal of the Association of European Psychiatrists · 2024Article
- Multiomics and blood-based biomarkers of electroconvulsive therapy in severe and treatment-resistant depression: study protocol of the DetECT study.European archives of psychiatry and clinical neuroscience · 2024Article
- Care pathways, prescribing practices and treatment outcomes in major depressive disorder and treatment-resistant depression: retrospective, population-based cohort study.BJPsych open · 2024Article
- Article
- The prevalence and economic burden of treatment-resistant depression in Thailand.BMC public health · 2023Article
- The Individual and Societal Burden of Treatment-Resistant Depression: An Overview.The Psychiatric clinics of North America · 2023Review
- Treatment-resistant depression and risk of autoimmune diseases: evidence from a population-based cohort and nested case-control study.Translational psychiatry · 2023Article
- Study to determine the epidemiology of treatment-resistant depression among the Saudi Arabian population: A cross-sectional study.Journal of education and health promotion · 2023Article
- Repetitive transcranial magnetic stimulation may be a cost-effective alternative to antidepressant therapy after two treatment failures in patients with major depressive disorder.BMC psychiatry · 2022Article
- The burden associated with, and management of, difficult-to-treat depression in patients under specialist psychiatric care in the United Kingdom.Journal of psychopharmacology (Oxford, England) · 2022Article
- Novel drug developmental strategies for treatment-resistant depression.British journal of pharmacology · 2022Review
- Clinical and Biological Factors Are Associated with Treatment-Resistant Depression.Behavioral sciences (Basel, Switzerland) · 2022Article
- Treatment-Resistant Depression in Poland-Epidemiology and Treatment.Journal of clinical medicine · 2022Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTreatment-resistant depression (TRD) is associated with a poor quality of life and high economic burden. This observational retrospective epidemiological study aimed to estimate the proportion of patients with TRD within a cohort of patients with major depressive disorder (MDD) in Hungary and examine the mortality and comorbidities of patients with and without TRD. PATIENTS AND
methodsThis study included patients with MDD who experienced onset of a new depressive episode between 01 January 2009 and 31 August 2015, using data from a nationwide, longitudinal database.
resultsOverall, 99,531 patients were included in the MDD cohort, of which 8,268 (8.3%) also met the criteria for TRD. The overall survival of non-TRD patients was longer than in TRD patients; the risk of mortality for TRD patients was significantly higher than of non-TRD patients (HR [CI] 1.381 [1.212-1.571]; p<0.001). Patients with TRD had a significantly higher probability of having "Neurotic, stress-related and somatoform disordersˮ, autoimmune conditions, cardio- or cerebrovascular diseases, thyroid gland diseases and self-harming behaviour not resulting in death than non-TRD patients (for all comparisons, p values were less than 0.005). DISCUSSION: To our best knowledge, this is the first study to assess the frequency of TRD in Hungary. In a cohort of Hungarian MDD patients, we have found that the proportion of TRD (~8.3%) is comparable to those reported in previous studies with similar methodology from other countries. The majority of our other main findings (e.g. more frequent self-harming behaviour, increased risk of "Neurotic, stress-related and somatoform disordersˮ and higher overall mortality in TRD subjects) are also in line with previous results from other countries. Taking the substantial proportion of patients with TRD into consideration, a more comprehensive and targeted treatment strategy would be required for these individuals.
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