ArticlePloS one2021
Reference intervals for selected haematological and biochemical parameters among apparently healthy adults in different eco-geographical zones in Ghana.
Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed.
- Physiological and biochemical indicators in blood of captive yellow-cheeked gibbons and northern white-cheeked gibbons.BMC veterinary research · 2025Article
- Hematological reference intervals for adult population of Debre Berhan town, North East Ethiopia.Scientific reports · 2025Article
- Reference intervals of Cyfra21-1 and CEA in healthy adult Han Chinese population.Practical laboratory medicine · 2024Article
- Dimension reduction and outlier detection of 3-D shapes derived from multi-organ CT images.BMC medical informatics and decision making · 2024Article
- Derivation of Russian-specific reference intervals for complete blood count, iron markers and related vitamins.PloS one · 2024Article
- Complete Blood Count Reference Intervals for Children Aged Less Than 1 to 12 Years in the Northern Region of Ghana.BioMed research international · 2024Article
- Estimation of parasitaemia in imported falciparum malaria using the results of a combined rapid diagnostic test. No big help from haematological parameters.Malaria journal · 2023Observational
- Blood count reference intervals for the Brazilian adult population: National Health Survey.Revista brasileira de epidemiologia = Brazilian journal of epidemiology · 2023Article
- Establishing pregnancy-specific haematological reference intervals in Ghana; a three-center cross-sectional study.PloS one · 2023Article
- Differences between reference intervals of blood counts of Brazilian adults with and without sickle cell trait according to laboratory tests from the National Health Survey.Revista brasileira de epidemiologia = Brazilian journal of epidemiology · 2023Article
- Establishment of reference intervals for hematological parameters of adult population in the western region of Saudi Arabia.PloS one · 2023Article
- Region-specific laboratory reference intervals are important: A systematic review of the data from Africa.PLOS global public health · 2022Article
- Variation in normative values of major clinical biochemistry analytes in healthy reproductive-age women in India: A subset of data from a National Indian Council of Medical Research-Polycystic Ovary Syndrome task force study.Indian journal of pharmacologyArticle
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11 authors.
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Abstract
backgroundDue to the influence of gender, race/genetics, age, lifestyle habits and geography on the references intervals (RIs), the Clinical and Laboratory Standards Institute (CLSI) recommends the determination of population-specific RIs. Ghana continues to depend on pre-established RIs from other countries which poses the risk of misdiagnoses and wrong treatment. This study presents the haemato-biochemical RIs from four eco-geographical zones in Ghana.
methodsIn this population-based cross-sectional study, a total of 1227 randomly selected healthy voluntary blood donors from the four eco-geographic zones (Coastal Savannah, Rain Forest, Savannah and Transitional) were enrolled and screened. Based on the CLSI Guidance Document C28A2992, the data of eligible participants were used to non-parametrically determine the RIs for the haemato-biochemical parameters at the 2.5th and 97.5th percentiles. Comparison of analytes by gender was done by Wilcoxon rank sum test and eco-geographic differences were assessed using the Kruskal-Wallis with the Dunn post hoc multiple comparison tests.
resultsThere were statistically significant differences in most of the haematological parameters (RBC, Hb, HCT, MCV, PLT, WBC; p-values <0.0001 and MCH; p-value = 0.007), and biochemical analytes (Urea, Cr, Trig, HDL-C, AST, ALT, ALP, GGT, BID, BIT, Prot-T and Albumin; p-values <0.0001) based on gender. Significant inter eco-geographic (intra-population) variations and substantial differences between the established RI and the RIs accompanying the analyzers used were also observed.
conclusionThis study reports significant inter-sex and inter-geographical differences in haemato-biochemical RIs in Ghana as well as differences in RIs with both the RIs accompanying the analyzers and those of other countries. Determining RIs representative of populations and including them in the report systems of laboratories to ensure effective and efficient healthcare service delivery is thus recommended.
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