ArticleJournal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53
Epigenetic Age Acceleration and Risk for Posttraumatic Stress Disorder following Exposure to Substantiated Child Maltreatment.
Article in Journal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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Who cites it
14 citing papers in PubMed, 23 citations in OpenAlex.
- Review
- Review
- Epigenetic signatures of intergenerational exposure to violence in three generations of Syrian refugees.Scientific reports · 2025Article
- Article
- Intervening After Trauma: Child-Parent Psychotherapy Treatment Is Associated With Lower Pediatric Epigenetic Age Acceleration.Psychological science · 2024Article
- Childhood Maltreatment and Biological Aging in Middle Adulthood: The Role of Psychiatric Symptoms.Biological psychiatry global open science · 2024Article
- Childhood Maltreatment and Longitudinal Epigenetic Aging: NIMHD Social Epigenomics Program.JAMA network open · 2024Article
- Examining epigenetic aging in the post-mortem brain in attention deficit hyperactivity disorder.Frontiers in genetics · 2024Article
- The relationship between childhood maltreatment and self-harm: the mediating roles of alexithymia, dissociation, internalizing and posttraumatic symptoms.European journal of psychotraumatology · 2024Article
- The association of epigenetic age acceleration and depressive and anxiety symptom severity among children recently exposed to substantiated maltreatment.Journal of psychiatric research · 2023Article
- Associations of stress and stress-related psychiatric disorders with GrimAge acceleration: review and suggestions for future work.Translational psychiatry · 2023Review
- Psychological and biological mechanisms linking trauma with cardiovascular disease risk.Translational psychiatry · 2023Review
- Psychotherapeutic Change Mechanisms and Causal Psychotherapy: Applications to Child Abuse and Trauma.Journal of child & adolescent trauma · 2022Article
- The pediatric buccal epigenetic clock identifies significant ageing acceleration in children with internalizing disorder and maltreatment exposure.Neurobiology of stress · 2021Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 3 countries.
Funding
Abstract
objectiveChild maltreatment is among the strongest predictors of posttraumatic stress disorder (PTSD). However, less than 40% of children who have been maltreated are ever diagnosed with PTSD, suggesting that exposure to child maltreatment alone is insufficient to explain this risk. This study examined whether epigenetic age acceleration, a stress-sensitive biomarker derived from DNA methylation, explains variation in PTSD diagnostic status subsequent to child maltreatment.
methodChildren and adolescents (
resultsEpigenetic age acceleration predicted current PTSD status, revealing an effect size magnitude in the moderate range,
conclusionsThe biological embedding of child maltreatment may explain variation in PTSD diagnostic status and serve as a novel approach for informing selective prevention or precision-based therapeutics for those at risk for PTSD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.