Evidence map›Paper›PMID 33471363›Full record

ReviewAmerican journal of hematology2021

Parenteral iron therapy and phosphorus homeostasis: A review.

Kamyar Kalantar-Zadeh, Tomas Ganz, Henry Trumbo, Melvin H Seid, Lawrence T Goodnough, Michael A Levine

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in American journal of hematology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Intravenous iron reactions: Insights from an allergy and immunology perspective.The journal of allergy and clinical immunology. Global · 2025
    Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Review
  18. Ferric carboxymaltose-induced hypophosphatemia in the Axenfeld-Reiger syndrome.Proceedings (Baylor University. Medical Center) · 2022
    Article
  19. An Expert Perspective on Phosphate Dysregulation With a Focus on Chronic Hypophosphatemia.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2022
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 6 institutions in 1 country.

Kamyar Kalantar-ZadehDivision of Nephrology and Hypertension and Kidney Transplantation, University of California Irvine, Orange, California, USA.
Tomas GanzDavid Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA.ORCID 0000-0002-2830-5469
Henry TrumboSt. Mary Medical Center, Langhorne, Pennsylvania, USA.
Melvin H SeidDepartment of Obstetrics and Gynecology, University of Southern California Verdugo Hills Hospital, Glendale, California, USA.
Lawrence T GoodnoughDepartment of Pathology and Medicine, Stanford University, Stanford, California, USA.
Michael A LevineCenter for Bone Health and Division of Endocrinology and Diabetes, Children's Hospital of Philadelphia and University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Children's Hospital of Philadelphia · USStanford Medicine · USSt. Mary Medical Center · USUniversity of California, Irvine · USUniversity of California, Los Angeles · USUniversity of Southern California · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Phosphorus has an essential role in cellular and extracellular metabolism; maintenance of normal phosphorus homeostasis is critical. Phosphorus homeostasis can be affected by diet and certain medications; some intravenous iron formulations can induce renal phosphate excretion and hypophosphatemia, likely through increasing serum concentrations of intact fibroblast growth factor 23. Case studies provide insights into two types of hypophosphatemia: acute symptomatic and chronic hypophosphatemia, while considering the role of pre-existing conditions and comorbidities, medications, and intravenous iron. This review examines phosphorus homeostasis and hypophosphatemia, with emphasis on effects of iron deficiency and iron replacement using intravenous iron formulations.

Indexed as

Anemia, HypochromicCalcitriolFerric CompoundsFibroblast Growth Factor-23Fibroblast Growth FactorsHomeostasisHumansHypophosphatemiaInfusions, ParenteralIronIron DeficienciesKidneyMalabsorption SyndromesMaltoseOsteomalaciaParathyroid HormoneCalcitriolferric carboxymaltoseFerric CompoundsFibroblast Growth Factor-23Fibroblast Growth FactorsIronMaltoseParathyroid HormonePhosphorusPhosphorus, Dietary

Identifiers

PMID33471363
PMCPMC8248123
OpenAlexW3123002409

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.