Evidence map›Paper›PMID 33471295›Full record

ArticleNeurochemical research2021

Syringin Prevents Aβ

Nan Zhang, Li Zhao, Yan Su, Xiaoliang Liu, Feilong Zhang, Yiwen Gao

Abstract read
PubMed Publisher
In one paragraph

Article in Neurochemical research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Nan Zhang *Department of Geriatrics, Yantai Affiliated Hospital of Binzhou Medical University, Yantai, Shandong, China.
Li Zhao *Department of Pharmacy, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, Shandong, China.
Yan SuMedical Service, Yantai Affiliated Hospital of Binzhou Medical University, Yantai, Shandong, China.
Xiaoliang LiuDepartment of Neurosurgery, Yantai Affiliated Hospital of Binzhou Medical University, Yantai, Shandong, China.
Feilong ZhangPublic Health Division, Yantai Affiliated Hospital of Binzhou Medical University, Yantai, Shandong, China.
Yiwen GaoDepartment of Pharmacy, Yantai Affiliated Hospital of Binzhou Medical University, No. 717, Jinbu Street, MuPing District, Yantai, 264100, Shandong, China. tqjjwl@163.com.
Binzhou University · CNBinzhou Medical University · CNYuhuangding Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alzheimer's disease (AD) is a neurodegenerative disorder disease, disturbing people's normal life. Syringin was mentioned to antagonize Amyloid-β (Aβ)-induced neurotoxicity. However, the action mechanism is still not fully elucidated. This study aimed to explore a molecular mechanism of syringin in defending Aβ-induced neurotoxicity. SK-N-SH and SK-N-BE cells were treated with amyloid β-protein fragment 25-35 (Aβ

Indexed as

Amyloid beta-PeptidesApoptosisBH3 Interacting Domain Death Agonist ProteinCell Line, TumorCell SurvivalDown-RegulationGlucosidesHumansMicroRNAsPeptide FragmentsPhenylpropionatesSignal TransductionUp-RegulationAmyloid beta-Peptidesamyloid beta-protein (25-35)BH3 Interacting Domain Death Agonist ProteinBID protein, humanGlucosidesMicroRNAsMIRN124 microRNA, humanPeptide FragmentsPhenylpropionatessyringinAlzheimer’s diseaseAβ25–35BIDmiR-124-3pSyringin

Identifiers

PMID33471295
OpenAlexW3125646025

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.