Evidence map›Paper›PMID 33471265›Full record

ArticleCell stress & chaperones2021

Effect of Nrf2 signaling pathway on the improvement of intestinal epithelial barrier dysfunction by hyperbaric oxygen treatment after spinal cord injury.

Xuehua Liu, Fang Liang, Wei Song, Xiaoli Diao, Wanqiu Zhu, Jing Yang

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell stress & chaperones, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 22 citations in OpenAlex.

  1. Hyperbaric Oxygen Therapy in Experimental Autoimmune Myocarditis: Insights from Preclinical Models to Translational Perspectives.Pathophysiology : the official journal of the International Society for Pathophysiology · 2026
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  19. Survey of Molecular Mechanisms of Hyperbaric Oxygen in Tissue Repair.International journal of molecular sciences · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Xuehua LiuDepartment of Hyperbaric Oxygen Medicine, Beijing Chaoyang Hospital, Capital Medical University, 8 Gongti South Road, Chaoyang District Beijing, Beijing, 100020, China.
Fang LiangDepartment of Hyperbaric Oxygen Medicine, Beijing Chaoyang Hospital, Capital Medical University, 8 Gongti South Road, Chaoyang District Beijing, Beijing, 100020, China.
Wei SongDepartment of Gastroenterology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.
Xiaoli DiaoDepartment of Pathology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.
Wanqiu ZhuDepartment of Hyperbaric Oxygen Medicine, Beijing Chaoyang Hospital, Capital Medical University, 8 Gongti South Road, Chaoyang District Beijing, Beijing, 100020, China.
Jing YangDepartment of Hyperbaric Oxygen Medicine, Beijing Chaoyang Hospital, Capital Medical University, 8 Gongti South Road, Chaoyang District Beijing, Beijing, 100020, China. JYANG2postgraduate@yeah.net.ORCID 0000-0002-9514-9558
Capital Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Disruption of the intestinal epithelial barrier following spinal cord injury (SCI) seriously affect long-term quality of life. Oxidative stress-induced epithelial cells' injury contributes to the epithelial barrier dysfunction. Hyperbaric oxygen (HBO) treatment has been proved to alleviate SCI. However, it is unclear whether or not HBO treatment affects intestinal barrier function following SCI. In this study, our purpose was to explore the impact of HBO treatment on intestinal epithelial barrier function and underlying mechanisms following SCI. An SCI model was established in rats, and the rats received HBO treatment. Intestinal injury, mucosal permeability, intercellular junction proteins, and oxidative stress indicators were evaluated in our study. We found that HBO treatment significantly alleviated intestinal histological damage, reduced mucosal permeability, and markedly prevented bacterial translocation. Furthermore, HBO treatment significantly increased the expression of Claudin-1 and E-cadherin, inhibited intestinal tissue oxidative stress as demonstrated by upregulation of superoxide dismutase and glutathione, and HBO downregulated malondialdehyde. Mechanically, we demonstrated that HBO treatment ameliorated intestinal oxidative stress possibly through upregulating nuclear factor E2-related factor 2 (Nrf2) and its downstream targets, Heme oxygenase-1(HO-1), NADH-quinone oxidoreductase-1(NQO-1), and glutamate cysteine ligase catalytic subunit (GCLC). These results suggested that HBO treatment triggered antioxidative effects against intestinal epithelial barrier dysfunction by promoting Nrf2 signaling pathway after SCI.

Indexed as

AnimalsHeme Oxygenase (Decyclizing)Hyperbaric OxygenationMaleNAD(P)H Dehydrogenase (Quinone)NF-E2-Related Factor 2RatsRats, Sprague-DawleySpinal Cord InjuriesTreatment OutcomeHeme Oxygenase (Decyclizing)Hmox1 protein, ratNAD(P)H Dehydrogenase (Quinone)Nfe2l2 protein, ratNF-E2-Related Factor 2NQO1 protein, ratHyperbaric oxygenIntestinal epithelial barrierNrf2 signaling pathwaySpinal cord injury

Identifiers

PMID33471265
PMCPMC7925733
OpenAlexW3125430527

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.