Evidence map›Paper›PMID 33471261›Full record

ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2021

Thrombophilic alterations, migraine, and vascular disease: results from a case-control study.

Cinzia Cavestro, Diana Degan, Gianmatteo Micca, Raffaele Aloi, Silvia Mandrino, Maria Cristina Frigeri, Francesca Pistoia, Filippo Molinari, Simona Sacco

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Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Headache in Workers: A Matched Case-Control Study.European journal of investigation in health, psychology and education · 2022
    Article
  4. Neurologic Manifestations of Catastrophic Antiphospholipid Syndrome.Current neurology and neuroscience reports · 2022
    Review
  5. Article
  6. Neurologic Manifestations of the Antiphospholipid Syndrome - an Update.Current neurology and neuroscience reports · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Cinzia CavestroHeadache Center, Department of Neurology, 'San Lazzaro' Hospital, ASL CN2, Alba, Italy. cicaves@alice.it.ORCID http://orcid.org/0000-0003-1172-1009
Diana DeganInstitute of Neurology, Department of Applied Clinical Sciences and Biotechnology, University of L'Aquila, L'Aquila, Italy.
Gianmatteo MiccaMain Laboratory and Hematology and Coagulation Disorders Laboratory, ASL CN2, Alba, Italy.
Raffaele AloiOccupational Medicine Service, ASL CN2, Alba, Italy.
Silvia MandrinoHeadache Center, Department of Neurology, 'San Lazzaro' Hospital, ASL CN2, Alba, Italy.
Maria Cristina FrigeriAdministrative Medical Office, 'San Lazzaro' Hospital, ASL CN2, Alba, Italy.
Francesca PistoiaInstitute of Neurology, Department of Applied Clinical Sciences and Biotechnology, University of L'Aquila, L'Aquila, Italy.
Filippo MolinariMain Laboratory and Hematology and Coagulation Disorders Laboratory, ASL CN2, Alba, Italy.
Simona SaccoInstitute of Neurology, Department of Applied Clinical Sciences and Biotechnology, University of L'Aquila, L'Aquila, Italy.
Azienda Sanitaria Locale CN2 · ITUniversity of L'Aquila · ITAzienda Sanitaria Ospedaliera S.Croce e Carle Cuneo · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe association between thrombophilic alterations, migraine, and vascular events has been broadly investigated but not been completely clarified.

methodsIn this cross-sectional, case-control study, we included consecutive outpatients diagnosed with migraine referring to a tertiary headache center. Migraine patients were matched to headache-free control subjects. All participants were evaluated for free protein S anticoagulant, functional protein C anticoagulant, homocysteine, and antiphospholipid antibodies (aPLs). History of ischemic stroke (IS) or transient ischemic attack (TIA), coronary heart disease, and peripheral venous thrombosis was also ascertained.

resultsWe included 329 migraine patients and 329 control subjects (mean age 41 years, 77% women in both groups). Among migraine patients, 239 (72.6%) had migraine without aura and 90 (27.4%) had migraine with aura. Migraine patients had more frequently arterial hypertension, hypercholesterolemia, history of IS or TIA and, peripheral venous thrombosis compared to control subjects, whereas we found no differences in diabetes mellitus, BMI, and coronary heart disease between the two groups. At least one thrombophilic alteration was detected in 107 (32.5%) migraine patients and in 74 (22.5%) control subjects (OR = 1.66, 95% CI 1.17-2.35, p = 0.004). We identified an association of migraine with aPL positivity (OR = 2.6, 95% CI 1.5-4.7, p = 0.001) and with free protein S deficiency (OR = 4.7, 95% CI 1.6-14.0, p = 0.002), whereas we found no differences in protein C deficiency, APCR, and hyperhomocysteinemia between the two groups. Furthermore, aPL positivity and free protein S deficiency were more common in migraine patients with and without aura than in control subjects. We found that in migraine patients, aPL positivity was associated with both IS or TIA (OR = 5.6, 95% CI 1.5-20.4, p = 0.009) and with coronary heart disease (OR = 27.6, 95% CI 1.4-531.1, p = 0.028), whereas free protein S deficiency was associated with IS or TIA only (OR = 14.3, 95% CI 2.8-74.4, p = 0.002).

conclusionsOur research documented a significative higher prevalence of aPL positivity and protein S deficiency in migraineurs than in controls. Data also showed an association between these alterations and some vascular thrombotic events in migraine patients. We can argue that thrombophilic disorders associated with migraine may contribute to the occurrence of vascular events.

Indexed as

Migraine DisordersThrombosisAdultCase-Control StudiesCross-Sectional StudiesFemaleHumansMaleRisk FactorsAntiphospholipid antibodiesHematologic diseasesMigraine disordersProtein S deficiencyStrokeThrombophilias

Identifiers

PMID33471261
OpenAlexW3121733261

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.