Evidence map›Paper›PMID 33471231›Full record

ReviewJournal of assisted reproduction and genetics2021

Extracellular vesicles and female reproduction.

Ronit Machtinger, Andrea A Baccarelli, Haotian Wu

Abstract readReview
In one paragraph

Review in Journal of assisted reproduction and genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
  5. The Influence of Ovarian-Derived Extracellular Vesicles in Reproduction.Advances in anatomy, embryology, and cell biology · 2026
    Review
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  11. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Ronit MachtingerSheba Medical Center, Ramat Gan and Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel. Ronit.Machtinger@sheba.health.gov.il.
Andrea A BaccarelliEnvironmental Precision Biosciences Laboratory, Columbia University, Mailman School of Public Health, New York, NY, USA.
Haotian WuEnvironmental Precision Biosciences Laboratory, Columbia University, Mailman School of Public Health, New York, NY, USA.

Funding

True Metal fac coreP30ES009089 · NIEHS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MATTHEW S PERZANOWSKI · 1998 to 2026
$44.7M
Translational Research Support CoreP30ES000002 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI JAIME ELIZABETH HART · 1985 to 2026
$44.6M
Circulating microRNAs in Extracellular Vesicles, Air Particulate Pollution, and Lung Function in an Aging CohortR01ES025225 · NIEHS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BACCARELLI, ANDREA · 2016 to 2020
$2.9M
Air Particulate Pollution and Stress: Effects and Mechanisms for Long-term Maternal Obesity RisksR01ES032242 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI COLICINO, ELENA, WU, HAOTIAN · 2020 to 2024
$2.2M
NIEHS NIH HHS P30 ES000002NIEHS NIH HHS P30 ES009089NIEHS NIH HHS R01 ES025225NIEHS NIH HHS R01 ES032242NIH HHS RO1 ES025225 06NIH HHS RO1 ES032242 01
6 · The paper itself

Abstract

Extracellular vesicles (EVs) are nano-sized membrane bound complexes that have been identified as a mean for intercellular communication between cells and tissues both in physiological and pathological conditions. These vesicles contain numerous molecules involved in signal transduction including microRNAs, mRNAs, DNA, proteins, lipids, and cytokines and can affect the behavior of recipient cells. Female reproduction is dependent on extremely fine-tuned endocrine regulation, and EVs may represent an added layer that contributes to this regulation. This narrative review article provides an update on the research of the role of EVs in female reproduction including folliculogenesis, fertilization, embryo quality, and implantation. We also highlight potential pitfalls in typical EV studies and discuss gaps in the current literature.

Indexed as

Embryo ImplantationReproductionExtracellular VesiclesFemaleHumansOvarian FollicleBlastocystEmbryosExtracellular vesiclesInfertilitymiRNA

Identifiers

PMID33471231
PMCPMC7910356

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.