ArticleJournal of assisted reproduction and genetics2021
Severe ovarian hyperstimulation syndrome associated with long-acting GnRH agonist in oncofertility patients.
Article in Journal of assisted reproduction and genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- Oocyte and embryo cryopreservation before gonadotoxic treatments: Principles of safe ovarian stimulation, a systematic review.Women's health (London, England)Pooled it
- Case Report: A diagnostic challenge: rare adverse effects of GnRH analogue therapy in a late pubertal pediatric patient.Frontiers in pediatrics · 2026Article
- Enhancing frozen-thawed embryo transfer outcomes and treatment personalization through machine learning models.Journal of assisted reproduction and genetics · 2025Article
- The silent protectors: how neutrophils influence female fertility during cancer treatment - a narrative review.Annals of medicine and surgery (2012) · 2025Review
- Exploring new frontiers in oncofertility preservation: a case of ovarian stimulation during pregnancy.Journal of ovarian research · 2025Article
- Fertility Preservation in Female Patients with Cancer Part II: Royan Institute Clinical Practice Guideline for Girls and Women with Cancer; A Review Study.International journal of fertility & sterility · 2025Article
- Changing the Perspective on Fertility Preservation for Women with Metastatic or Advanced Stage Cancer.Current oncology reports · 2024Review
- Long-acting gonadotropin-releasing hormone agonist trigger in fertility preservation cycles before chemotherapy.ESMO open · 2023Article
- Coenzyme Q10 improves ovarian histology and attenuates the expression of angiogenesis-associated proteins in the ovary of rats with experimental hyperstimulation syndrome.Iranian journal of basic medical sciences · 2022Article
- Assessment of Knowledge, Attitude, and Practice of Obstetricians and Gynecologists Toward Off-Label Medicine Use in Female Reproductive Health Issues.Frontiers in public health · 2022Article
- The Treatment of Complementary and Alternative Medicine on Female Infertility Caused by Endometrial Factors.Evidence-based complementary and alternative medicine : eCAM · 2022Review
- In reply to: Christ J, Herndon CN, Yu B. Severe ovarian hyperstimulation syndrome associated with long-acting GnRH agonist in oncofertility patients. J Assist Reprod Genet. 2021;38:751-6. doi:10.1007/s10815-020-02051.Journal of assisted reproduction and genetics · 2021Article
- Severe Ovarian Hyperstimulation Syndrome in a Woman With Breast Cancer Under Letrozole Triggered With GnRH Agonist: A Case Report and Review of the Literature.Frontiers in reproductive health · 2021Article
- Risk of ovarian hyperstimulation syndrome in women with malignancies undergoing treatment with long-acting gonadotropin-releasing hormone agonist after controlled ovarian hyperstimulation for fertility preservation: a systematic review.Therapeutic advances in reproductive healthReview
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
purposeTo report three cases of severe ovarian hyperstimulation syndrome (OHSS) among oncofertility patients receiving a long-acting GnRH agonist for ovarian suppression after controlled ovarian hyperstimulation (COH) with a GnRH antagonist protocol
methodsChart abstraction was completed for three patients at a single academic medical center. Patients included were undergoing fertility preservation prior to gonadotoxic chemotherapy. All patients underwent COH with GnRH antagonist protocol and embryo cryopreservation immediately followed by ovarian suppression with long-acting GnRH agonist. Main outcome measure was development of OHSS.
resultsDespite using GnRH agonist trigger and freezing all embryos, patients developed ascites, intermittent hyponatremia and hemoconcentration consistent with severe early-onset OHSS after receiving long-acting GnRH agonist immediately following oocyte retrieval for ovarian preservation.
conclusionsRisk of severe OHSS may be increased when a long-acting GnRH agonist is used for ovarian suppression immediately following oocyte retrieval. A delay in initiating long-acting GnRH agonist after oocyte retrieval in patients at high risk for developing OHSS should be considered.
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Registered trials
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