ArticleACS nano2021
Doing What Spiders Cannot-A Road Map to Supreme Artificial Silk Fibers.
Article in ACS nano, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 57 citations in OpenAlex.
- Limpet-Inspired Multifunctional Composite Fibers with Exceptional Mechanical Performance From Self-Assembled Aramid Nanofibers.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Charting the envelope of mechanical properties of synthetic silk fibers through predictive modeling of the drawing process.Science advances · 2025Article
- Artificial Spidroin Nanogenerator-Based Articulus Wound Dressing.ChemistryOpen · 2025Article
- Progress in Multiscale Modeling of Silk Materials.Biomacromolecules · 2024Review
- Strategies for Making High-Performance Artificial Spider Silk Fibers.Advanced functional materials · 2024Review
- Biocomposite Materials Derived fromMaterials (Basel, Switzerland) · 2024Article
- Manipulating Microbial Cell Morphology for the Sustainable Production of Biopolymers.Polymers · 2024Review
- Bioplastics: Innovation for Green Transition.Polymers · 2023Review
- Molecular mechanisms of the high performance of spider silks revealed through multi-omics analysis.Biophysics and physicobiology · 2023Article
- Rapid molecular diversification and homogenization of clustered major ampullate silk genes in Argiope garden spiders.PLoS genetics · 2022Article
- Review
- 1000 spider silkomes: Linking sequences to silk physical properties.Science advances · 2022Article
- Engineered Spider Silk Proteins for Biomimetic Spinning of Fibers with Toughness Equal to Dragline Silks.Advanced functional materials · 2022Article
- A spider silk-derived solubility domain inhibits nuclear and cytosolic protein aggregation in human cells.Communications biology · 2022Article
- Artificial and natural silk materials have high mechanical property variability regardless of sample size.Scientific reports · 2022Article
- Stress Dissipation Encoded Silk Fibroin Electrode for the Athlete-Beneficial Silk Bioelectronics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- Darwin's bark spider shares a spidroin repertoire withOpen biology · 2021Article
- Hydrogel Preparation Methods and Biomaterials for Wound Dressing.Life (Basel, Switzerland) · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fabricating artificial spider silk fibers in bulk scale has been a major goal in materials science for centuries. Two main routes have emerged for making such fibers. One method uses biomimetics in which the spider silk proteins (spidroins) are produced under nativelike conditions and then spun into fibers in a process that captures the natural, complex molecular mechanisms. However, these fibers do not yet match the mechanical properties of native silk fibers, potentially due to the small size of the designed spidroin used. The second route builds on biotechnological progress that enables production of large spidroins that can be spun into fibers by using organic solvents. With this approach, fibers that equal the native material in terms of mechanical properties can be manufactured, but the yields are too low for economically sustainable production. Hence, the need for new ideas is urgent. Herein, we introduce a structural-biology-based approach for engineering artificial spidroins that circumvents the laws with which spidroins, being secretory proteins, have to comply in order to avoid membrane insertion and provide a road map to the production of biomimetic silk fibers with improved mechanical properties.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.