Evidence map›Paper›PMID 33470467›Full record

ArticleJournal of orthopaedic research : official publication of the Orthopaedic Research Society2021

Staphylococcal infection prevention using antibiotic-loaded mannitol-chitosan paste in a rabbit model of implant-associated osteomyelitis.

Zoe L Harrison, Leslie R Pace, Madison N Brown, Karen E Beenken, Mark S Smeltzer, Joel D Bumgardner, Warren O Haggard, J Amber Jennings

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Zoe L HarrisonDepartment of Biomedical Engineering, University of Memphis, Memphis, Tennessee, USA.ORCID 0000-0002-5276-450X
Leslie R PaceDepartment of Biomedical Engineering, University of Memphis, Memphis, Tennessee, USA.
Madison N BrownDepartment of Biomedical Engineering, University of Memphis, Memphis, Tennessee, USA.
Karen E BeenkenDepartment of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
Mark S SmeltzerDepartment of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
Joel D BumgardnerDepartment of Biomedical Engineering, University of Memphis, Memphis, Tennessee, USA.
Warren O HaggardDepartment of Biomedical Engineering, University of Memphis, Memphis, Tennessee, USA.
J Amber JenningsDepartment of Biomedical Engineering, University of Memphis, Memphis, Tennessee, USA.ORCID 0000-0002-2760-6948
University of Memphis · USUniversity of Arkansas for Medical Sciences · US

Funding

Investigating a Flexible, Degradable, Local Antimicrobial Delivery SystemR01AR066050 · NIAMS · UNIVERSITY OF MEMPHIS · PI JENNINGS, JESSICA AMBER · 2015 to 2019
$1.5M
NIAMS NIH HHS R01 AR066050
6 · The paper itself

Abstract

Antibiotic-loaded chitosan pastes have shown advantages in the treatment and coverage of complex musculoskeletal defects. We added mannitol, previously shown to increase antibiotic susceptibility of biofilm, to an injectable chitosan/polyethylene glycol paste for delivery of antibiotics. Ground sponges (0.85% acetic acid solution, 1% chitosan, 0% or 2% mannitol, 1% polyethylene glycol) were hydrated using phosphate-buffered saline with 10 mg/ml amikacin and 10 mg/ml vancomycin added to form pastes. We inoculated rabbit radial defects with 10

Indexed as

ChitosanOsteomyelitisStaphylococcal InfectionsAnimalsAnti-Bacterial AgentsBiocompatible MaterialsMannitolPolyethylene GlycolsRabbitsTitaniumVancomycinAnti-Bacterial AgentsBiocompatible MaterialsChitosanMannitolPolyethylene GlycolsTitaniumVancomycinbiofilmchitosandrug delivery devicemannitolosteomyelitis

Identifiers

PMID33470467
PMCPMC8289950
OpenAlexW3121172046

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.