Evidence map›Paper›PMID 33470210›Full record

ReviewInternational journal of radiation oncology, biology, physics2021

Adaptive Radiation Therapy (ART) Strategies and Technical Considerations: A State of the ART Review From NRG Oncology.

Carri K Glide-Hurst, Percy Lee, Adam D Yock, Jeffrey R Olsen, Minsong Cao, Farzan Siddiqui, William Parker, Anthony Doemer, Yi Rong, Amar U Kishan and 6 more

Registry-linked trialAbstract readReview
In one paragraph

Review in International journal of radiation oncology, biology, physics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06492486 (Glioma Adaptive Radiotherapy With Development of an Artificial Intelligence Workflow), which is not on this map. Cited by 178 papers.

0numbers the graph read from it
0cells of the map it votes in
178citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06492486 phase2recruitingnot on this mapstarted 2026, after this paper: background citation

Glioma Adaptive Radiotherapy With Development of an Artificial Intelligence Workflow

TypeinterventionalSponsorTata Memorial CentreRan2026 to 2028Enrolled60ConditionsDiffuse Glioma, Glioblastoma, Adaptive Radiotherapy, Artificial IntelligenceArmsAdaptive radiotherapy
3 · Its place in the literature

Who cites it

178 citing papers in PubMed.

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  11. Biologically adaptive radiation oncology in oligometastatic and oligoprogressive disease: MR- and CBCT-guided adaptation, molecular imaging, dose painting, biomarkers, and AI.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
    Review
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118 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Carri K Glide-HurstDepartment of Human Oncology, University of Wisconsin-Madison, Madison, Wisconsin. Electronic address: glidehurst@humonc.wisc.edu.
Percy LeeDepartment of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas.
Adam D YockDepartment of Radiation Oncology, Vanderbilt University Medical Center, Nashville, Tennessee.
Jeffrey R OlsenDepartment of Radiation Oncology, University of Colorado- Denver, Denver, Colorado.
Minsong CaoDepartment of Radiation Oncology, University of California-Los Angeles, Los Angeles, California.
Farzan SiddiquiDepartment of Radiation Oncology, Henry Ford Cancer Institute, Detroit, Michigan.
William ParkerDepartment of Radiation Oncology, McGill University, Montreal, Quebec, Canada.
Anthony DoemerDepartment of Radiation Oncology, Henry Ford Cancer Institute, Detroit, Michigan.
Yi RongDepartment of Radiation Oncology, University of California-Davis, Sacramento, California.
Amar U KishanDepartment of Radiation Oncology, University of California-Los Angeles, Los Angeles, California.
Stanley H BenedictDepartment of Radiation Oncology, University of California-Davis, Sacramento, California.
X Allen LiDepartment of Radiation Oncology, Medical College of Wisconsin, Milwaukee, Wisconsin.
Beth A EricksonDepartment of Radiation Oncology, Medical College of Wisconsin, Milwaukee, Wisconsin.
Jason W SohnDepartment of Radiation Oncology, Allegheny Health Network, Pittsburgh, Pennsylvania.
Ying XiaoDepartment of Radiation Oncology, University of Pennsylvania, Philadelphia, Pennsylvania.
Evan WuthrickDepartment of Radiation Oncology, Moffitt Cancer Center, Tampa, Florida.

Funding

NRG Oncology Network Group Operations Center - GY9 BIQSFP Reports/BudgetsU10CA180868 · NCI · NRG ONCOLOGY FOUNDATION, INC. · PI NORMAN WOLMARK · 2014 to 2026
$206.8M
IROC: Enhancing local enrolling site radiological data capture capabilities for NCTN trialsU24CA180803 · NCI · AMERICAN COLLEGE OF RADIOLOGY · PI Thomas J. FitzGerald, MICHAEL V KNOPP · 2014 to 2026
$116.2M
Development of Anatomical Patient Models to Facilitate MR-only Treatment PlanningR01CA204189 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI GLIDE-HURST, CARRI KAYE · 2016 to 2020
$1.5M
NCI NIH HHS R01 CA204189NCI NIH HHS U10 CA180868NCI NIH HHS U24 CA180803
6 · The paper itself

Abstract

The integration of adaptive radiation therapy (ART), or modifying the treatment plan during the treatment course, is becoming more widely available in clinical practice. ART offers strong potential for minimizing treatment-related toxicity while escalating or de-escalating target doses based on the dose to organs at risk. Yet, ART workflows add complexity into the radiation therapy planning and delivery process that may introduce additional uncertainties. This work sought to review presently available ART workflows and technological considerations such as image quality, deformable image registration, and dose accumulation. Quality assurance considerations for ART components and minimum recommendations are described. Personnel and workflow efficiency recommendations are provided, as is a summary of currently available clinical evidence supporting the implementation of ART. Finally, to guide future clinical trial protocols, an example ART physician directive and a physics template following standard NRG Oncology protocol is provided.

Indexed as

BrachytherapyClinical Trials as TopicHumansOrgans at RiskQuality Assurance, Health CareRadiotherapy DosageRadiotherapy, Image-GuidedRadiotherapy Planning, Computer-AssistedTomography, X-Ray ComputedWorkflow

Identifiers

PMID33470210
PMCPMC8290862

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.