Evidence map›Paper›PMID 33470092›Full record

ArticleACS nano2021

Selection of Fluorescent, Bioluminescent, and Radioactive Tracers to Accurately Reflect Extracellular Vesicle Biodistribution

Elisa Lázaro-Ibáñez, Farid N Faruqu, Amer F Saleh, Andreia M Silva, Julie Tzu-Wen Wang, Janusz Rak, Khuloud T Al-Jamal, Niek Dekker

Open access · hybridAbstract read
In one paragraph

Article in ACS nano, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 167 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
167citing papers in PubMed, 1 pooled it
13.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

167 citing papers in PubMed, 1 synthesis or guideline pooled it, 242 citations in OpenAlex.

  1. Systematic review of changes in extracellular vesicles associated with obstructive sleep apnoea: implications for diagnosis and treatment.European respiratory review : an official journal of the European Respiratory Society · 2025
    Pooled it
  2. Review
  3. Article
  4. Review
  5. Review
  6. Review
  7. Review
  8. Review
  9. Article
  10. Article
  11. Extracellular vesicles: Navigating new frontiers in glioblastoma therapy.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026
    Review
  12. Review
  13. Article
  14. Review
  15. Article
  16. Article
  17. Review
  18. Review
  19. Article
  20. Review

107 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 3 countries.

Elisa Lázaro-IbáñezDiscovery Biology, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Gothenburg 43150, Sweden.ORCID 0000-0002-3542-7069
Farid N FaruquInstitute of Pharmaceutical Science, School of Cancer & Pharmaceutical Sciences, King's College London, London SE1 9NH, United Kingdom.
Amer F SalehFunctional and Mechanistic Safety, Clinical Pharmacology & Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge CB2 0AA, United Kingdom.
Andreia M SilvaDiscovery Biology, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Gothenburg 43150, Sweden.
Julie Tzu-Wen WangInstitute of Pharmaceutical Science, School of Cancer & Pharmaceutical Sciences, King's College London, London SE1 9NH, United Kingdom.
Janusz RakResearch Institute of the McGill University Health Centre, Glen Site, McGill University, Montreal, Quebec H4A 3J,1 Canada.ORCID 0000-0002-2912-5566
Khuloud T Al-JamalInstitute of Pharmaceutical Science, School of Cancer & Pharmaceutical Sciences, King's College London, London SE1 9NH, United Kingdom.ORCID 0000-0001-5165-2699
Niek DekkerDiscovery Biology, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Gothenburg 43150, Sweden.ORCID 0000-0001-8245-6041
AstraZeneca (Sweden) · SEKing's College London · GBAstraZeneca (United Kingdom) · GBMcGill University Health Centre · CA

Funding

Wellcome Trust
6 · The paper itself

Abstract

The ability to track extracellular vesicles (EVs)

Indexed as

Extracellular VesiclesRadioactive TracersAnimalsKineticsMiceMice, Inbred BALB CTissue DistributionRadioactive Tracersbiodistributiondeliveryexosomesextracellular vesiclesnuclear imagingoptical imagingvesicle tracers

Identifiers

PMID33470092
PMCPMC7905875
OpenAlexW3123997015

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.