ArticleJournal of gynecologic oncology2021
Substantial lymph-vascular space invasion (LVSI) as predictor of distant relapse and poor prognosis in low-risk early-stage endometrial cancer.
Article in Journal of gynecologic oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06306170 (Efficacy of Advanced Radiotherapy), which is not on this map. Cited by 58 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Efficacy of Advanced Radiotherapy (ART) in Gynecological Cancer Patients (GYN-ART)
Who cites it
58 citing papers in PubMed, 2 syntheses or guidelines pooled it, 88 citations in OpenAlex.
- Preoperative magnetic resonance imaging-radiomics in cervical cancer: a systematic review and meta-analysis.Frontiers in oncology · 2024Pooled it
- Evaluation of prognostic significance of lymphovascular space invasion in early stage endometrial cancer: a systematic review and meta-analysis.Frontiers in oncology · 2023Pooled it
- AKR1B1 and AKR1B10 as Potential Prognostic Biomarkers of Endometrial Cancer.International journal of molecular sciences · 2026Article
- Lymphovascular space invasion is associated with increased locoregional recurrence despite adjuvant radiotherapy in node-negative stage I-II endometrioid endometrial cancer.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026Article
- Deciphering survival disparities in endometrial cancer: a focus on mismatch repair pathway integrity (systematic review and meta-analysis).Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026Review
- Substantial LVSI Is Independently Associated with Para-Aortic Nodal Metastasis in Patients Undergoing Laparoscopic Surgical Staging for Endometrial Cancer.Current oncology (Toronto, Ont.) · 2026Article
- Prognostic Impact of WHO 2020 Lymphovascular Space Invasion Categories in Endometrial Cancer: Substantial LVSI as an Independent Risk Factor and the Behavior of LVSI-Positive, Node-Negative Disease.The journal of obstetrics and gynaecology research · 2026Article
- Development of an interpretable machine learning model for lymphovascular space invasion prediction in patients with endometrioid endometrial carcinoma: A prospective study.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2026Article
- Prominent Lymphovascular Space Invasion as an Independent Prognostic Factor in LVSI-Positive Endometrioid Endometrial Carcinoma: Evidence for a Novel Three-Tiered Classification.Journal of clinical medicine · 2026Article
- Evaluate lymphovascular space invasion in endometrial cancer using diffusion-weighted imaging-based habitat imaging.Scientific reports · 2025Article
- Ultrasound based radiomics nomogram combined with clinical parameters to predict lymphovascular space invasion in endometrioid adenocarcinoma.Scientific reports · 2025Article
- Additional Risk Factors Lead to a Measurable Inflammatory Response in Stage I Endometrial Cancer-A Prospective Multicentric Observational Study.Indian journal of surgical oncology · 2025Article
- Biological characteristics prediction of endometrial cancer based on deep convolutional neural network and multiparametric MRI radiomics.Abdominal radiology (New York) · 2025Article
- The Impact of Lymphovascular Space Invasion on Recurrence and Survival in FIGO Stage I Node-Negative Endometrioid Endometrial Cancer.Journal of clinical medicine · 2025Article
- Cancer of the corpus uteri: A 2025 update.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2025Review
- Multifactorial construction of low-grade and high-grade endometrial cancer recurrence prediction models.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2025Article
- Analysis of postoperative prognosis of non-metastatic endometrial carcinoma under different recurrence patterns.Scientific reports · 2025Article
- Overall survival after progression in patients with uterine carcinosarcoma: a single-center retrospective cohort study.Obstetrics & gynecology science · 2025Article
- Effect of substantial lymphovascular space invasion on location of first disease recurrence in surgical stage I endometrioid endometrial adenocarcinoma.International journal of gynecological cancer : official journal of the International Gynecological Cancer Society · 2025Article
- New FIGO 2023 Staging System of Endometrial Cancer: An Updated Review on a Current Hot Topic.Geburtshilfe und Frauenheilkunde · 2025Article
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe aim of this study is to analyze the prognostic role of lymph-vascular space invasion (LVSI), evaluated in a semi-quantitative fashion on prognosis of early stage, low risk endometrial cancer (EC).
methodsWe enrolled patients who underwent surgery for endometrial cancer between 2003 and 2018 in two referral cancer center. All patients had endometrioid EC, G1-G2, with myometrial invasion <50%, and no lymph-node involvement. LVSI was analyzed in a semi-quantitative way, according to a 3-tiered scoring system in absent, focal and substantial.
resultsAmong 524 patients, any positive LVSI was found in 57 patients (10.9%) with focal LVSI (n=35, 6.7%) and substantial LVSI (n=22, 4.2%). Substantial LVSI was associated to higher rate of G2 (p<0.001), myometrial infiltration (p=0.002) and greater tumor dimensions (p=0.014). Patients with substantial LVSI were more likely to receive adjuvant treatment (6.6% vs. 52.6%, p<0.001). The 5-year OS was 99.5% in patients with absent LVSI and 70.6% in those with substantial LVSI (p<0.001). The 5-year disease free survival (DFS) was 93.6% in patients with absent LVSI and 56.5% in those with substantial LVSI (p<0.001). The rate of distant failures increased from 1.8% for absent LVSI to 22.7% for substantial LVSI (p=0.002). In univariate analysis substantial LVSI was the strongest predictor of poor overall survival (hazard ratio [HR]=11.9, p=0.001). Multivariate analysis showed that substantial LVSI was an independent predictive factor of both recurrence (HR=5.88, p=0.001) and distant failure (HR=10.6, p=0.006).
conclusionsSubstantial LVSI represents the strongest independent risk factor for decreased survival and distant relapse, indicating a role for potential hematogenous dissemination.
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