Evidence map›Paper›PMID 33470055›Full record

ReviewWiley interdisciplinary reviews. Cognitive science2021

Combining transcranial magnetic stimulation with functional magnetic resonance imaging for probing and modulating neural circuits relevant to affective disorders.

Desmond J Oathes, Nicholas L Balderston, Konrad P Kording, Joseph A DeLuisi, Gianna M Perez, John D Medaglia, Yong Fan, Romain J Duprat, Theodore D Satterthwaite, Yvette I Sheline and 1 more

Open access · greenAbstract readReview
In one paragraph

Review in Wiley interdisciplinary reviews. Cognitive science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 45 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Trial
  4. Review
  5. Review
  6. Review
  7. Circuit-Based Approaches to Understanding the Anterior Cingulate Cortex (ACC).The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Review
  8. Article
  9. Article
  10. Review
  11. Microfabrication Technologies for Nanoinvasive and High-Resolution Magnetic Neuromodulation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Review
  12. Review
  13. Targeting the Hippocampus in the Context of Trauma.Biological psychiatry global open science · 2024
    Article
  14. Article
  15. Review
  16. Review
  17. Mechanisms of Action of TMS in the Treatment of Depression.Current topics in behavioral neurosciences · 2024
    Review
  18. The future of brain circuit-targeted therapeutics.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024
    Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Desmond J OathesCenter for Neuromodulation in Depression and Stress, Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.ORCID https://orcid.org/0000-0001-7346-2669
Nicholas L BalderstonCenter for Neuromodulation in Depression and Stress, Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Konrad P KordingDepartment of Neuroscience, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Joseph A DeLuisiCenter for Neuromodulation in Depression and Stress, Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Gianna M PerezCenter for Neuromodulation in Depression and Stress, Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
John D MedagliaDepartment of Psychology, Drexel University, Philadelphia, Pennsylvania, USA.
Yong FanCenter for Biomedical Image Computing and Analytics (CBICA), Department of Radiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Romain J DupratCenter for Neuromodulation in Depression and Stress, Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Theodore D SatterthwaiteLifespan Informatics and Neuroimaging Center, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Yvette I ShelineCenter for Neuromodulation in Depression and Stress, Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Kristin A LinnCenter for Neuromodulation in Depression and Stress, Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
University of Pennsylvania · USDrexel University · USLifespan · USPenn Center for AIDS Research · US

Funding

Individualized Closed Loop TMS for Working Memory EnhancementR01MH120811 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI FAN, YONG, OATHES, DESMOND · 2019 to 2023
$3.5M
Dimensional connectomics of anxious miseryU01MH109991 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI SHELINE, YVETTE I · 2016 to 2019
$2.8M
Network Control and Functional Context: Mechanisms for TMS ResponseRF1MH116920 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI BASSETT, DANIELLE SMITH, OATHES, DESMOND · 2018 to 2018
$2.8M
Non-invasive neuromodulation mechanisms and dose/response metricsR01MH111886 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI OATHES, DESMOND · 2016 to 2019
$2.7M
Virtual Resection to Treat EpilepsyR01NS099348 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI BASSETT, DANIELLE SMITH, LITT, BRIAN · 2016 to 2019
$2.3M
Dynamic Network Neuroscience and Control Theory: Toward Interventions for Cognitive Control DysfunctionDP5OD021352 · OD · UNIVERSITY OF PENNSYLVANIA · PI MEDAGLIA, JOHN · 2015 to 2019
$2.0M
Biomedical Image Computing and Informatics ClusterS10OD023495 · OD · UNIVERSITY OF PENNSYLVANIA · PI DAVATZIKOS, CHRISTOS · 2017 to 2017
$1.9M
Examining the mechanisms of anxiety regulation using a novel, sham-controlled, fMRI-guided rTMS protocol and a translational laboratory model of anxiety.K01MH121777 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI BALDERSTON, NICHOLAS LEE · 2019 to 2022
$723k
NIH HHS DP5 OD021352NIH HHS S10 OD023495NIMH NIH HHS K01 MH121777NIMH NIH HHS R01 MH111886NIMH NIH HHS R01 MH120811NIMH NIH HHS RF1 MH116920NIMH NIH HHS U01 MH 109991NIMH NIH HHS U01 MH109991NINDS NIH HHS R01 NS099348ODCDC CDC HHS DP5 OD021352
6 · The paper itself

Abstract

Combining transcranial magnetic stimulation (TMS) with functional magnetic resonance imaging offers an unprecedented tool for studying how brain networks interact in vivo and how repetitive trains of TMS modulate those networks among patients diagnosed with affective disorders. TMS compliments neuroimaging by allowing the interrogation of causal control among brain circuits. Together with TMS, neuroimaging can provide valuable insight into the mechanisms underlying treatment effects and downstream circuit communication. Here we provide a background of the method, review relevant study designs, consider methodological and equipment options, and provide statistical recommendations. We conclude by describing emerging approaches that will extend these tools into exciting new applications. This article is categorized under: Psychology > Emotion and Motivation Psychology > Theory and Methods Neuroscience > Clinical Neuroscience.

Indexed as

Magnetic Resonance ImagingTranscranial Magnetic StimulationBrainHumansMood DisordersNeuroimagingaffective disordersanxietydepressionfMRITMS

Identifiers

PMID33470055
PMCPMC8521438
OpenAlexW3124107815

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.