Evidence map›Paper›PMID 33470021›Full record

ArticlePediatric diabetes2021

Medical management of children with type 1 diabetes on low-carbohydrate or ketogenic diets.

Amy A Rydin, Gail Spiegel, Brigitte I Frohnert, Anne Kaess, Lauren Oswald, Darcy Owen, Kimber M Simmons

Registry-linked trialAbstract read
In one paragraph

Article in Pediatric diabetes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06273631 (Effect of Changes in Carbohydrate Intake Patterns on Glucose Control in Patients With Type 1 Diabetes), which is not on this map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06273631 narecruitingnot on this mapstarted 2024, after this paper: background citation

Effect of Changes in Carbohydrate Intake Patterns on Glucose Control in Patients With Type 1 Diabetes

TypeinterventionalSponsorYang TaoRan2024 to 2027Enrolled80ConditionsType 1 Diabetes, Diet Intervention, Glucose ControlArmsdiverse carbohydrate diet, moderate carbohydrate diet
3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Review
  6. Article
  7. Severe growth retardation during carbohydrate restriction in type 1 diabetes mellitus: A case report.Clinical pediatric endocrinology : case reports and clinical investigations : official journal of the Japanese Society for Pediatric Endocrinology · 2024
    Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Amy A RydinBarbara Davis Center for Diabetes, University of Colorado School of Medicine, Aurora, Colorado, USA.ORCID 0000-0003-2607-1950
Gail SpiegelBarbara Davis Center for Diabetes, University of Colorado School of Medicine, Aurora, Colorado, USA.
Brigitte I FrohnertBarbara Davis Center for Diabetes, University of Colorado School of Medicine, Aurora, Colorado, USA.
Anne KaessBarbara Davis Center for Diabetes, University of Colorado School of Medicine, Aurora, Colorado, USA.
Lauren OswaldBarbara Davis Center for Diabetes, University of Colorado School of Medicine, Aurora, Colorado, USA.
Darcy OwenBarbara Davis Center for Diabetes, University of Colorado School of Medicine, Aurora, Colorado, USA.
Kimber M SimmonsBarbara Davis Center for Diabetes, University of Colorado School of Medicine, Aurora, Colorado, USA.ORCID 0000-0003-0560-5773

Funding

Training Program in Diabetes ResearchT32DK063687 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI Andrea Steck · 2002 to 2026
$5.2M
K12 Career DevelopmentK12DK094712 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI STECK, ANDREA · 2011 to 2021
$4.5M
NIDDK NIH HHS 5 K12 DK094712-08NIDDK NIH HHS 5 T32 DK063687NIDDK NIH HHS K12 DK094712NIDDK NIH HHS T32 DK063687
6 · The paper itself

Abstract

objectivesLow-carbohydrate and ketogenic diets are becoming increasingly popular choices for people with type 1 diabetes (T1D) aiming to achieve optimal glycemic control. A carbohydrate-restricted diet in children has been associated with negative health effects including poor linear growth and inadequate bone mineralization. Guidelines for monitoring children and adolescents choosing to follow a carbohydrate-restricted diet do not exist. We aimed to create a clinical protocol outlining how to clinically and biochemically follow patients choosing a carbohydrate-restricted diet with the goal of medical safety.

methodsAn interdisciplinary committee was formed and reviewed current consensus guidelines for pediatric patients on carbohydrate-restricted diets for epilepsy and metabolic disorders. A literature search was done to determine management strategies for children with T1D on a low-carbohydrate or ketogenic diet. Key health parameters that require monitoring were identified: growth, glycemic control, bone health, cardiometabolic health, and nutritional status. These health outcomes were used to develop a protocol for monitoring children on carbohydrate-restricted diets.

resultsA one-page protocol for medical providers and educational materials for families interested in following a low-carbohydrate or ketogenic diet were developed and successfully implemented into clinical care.

conclusionImplementing a protocol for children on carbohydrate-restricted diets in clinic allows medical providers to ensure medical safety while being open to discussing a family's dietary preferences. Following children in the protocol over time will lead to informed clinical guidelines for patients with T1D who choose to follow a carbohydrate-restricted diet.

Indexed as

Diet, Carbohydrate-RestrictedDiet, KetogenicAdolescentChildClinical ProtocolsDiabetes Mellitus, Type 1HumansNutritional StatusPatient Education as Topiccarbohydrate-restricted dietketogenic dietpediatricstype 1 diabetes mellitus

Identifiers

PMID33470021
PMCPMC10038004

What OpenQuestion holds

Textmetadata
LicenceTDM
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.