Evidence map›Paper›PMID 33469997›Full record

ArticleJournal of cellular and molecular medicine2021

Bisphenol A at a human exposed level can promote epithelial-mesenchymal transition in papillary thyroid carcinoma harbouring BRAF

Liuli Li, Hao Li, Jun Zhang, Xin Gao, Hao Jin, Renqi Liu, Zhen Zhang, Xuan Zhang, Xichang Wang, Peng Qu and 2 more

Open access · goldAbstract read
In one paragraph

Article in Journal of cellular and molecular medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.0field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Review
  6. Review
  7. Article
  8. Up-regulation of NGEF via the BRAFBiochemistry and biophysics reports · 2025
    Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Sex Bias in Differentiated Thyroid Cancer.International journal of molecular sciences · 2021
    Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Liuli LiDepartment of Toxicology, School of Public health, China Medical University, Shenyang, China.
Hao LiDepartment of Toxicology, School of Public health, China Medical University, Shenyang, China.
Jun ZhangDepartment of Oromaxillofacial-Head and Neck Surgery, Department of Oral and Maxillofacial Surgery, School of Stomatology, China Medical University, Shenyang, China.
Xin GaoDepartment of head and Neck Surgery, Cancer Hospital of China Medical University/Liaoning Cancer Hospital & Institute, Shenyang, China.
Hao JinJin Zhou Center for Disease Control and Prevention, Jinzhou, China.
Renqi LiuJin Zhou Center for Disease Control and Prevention, Jinzhou, China.
Zhen ZhangJin Zhou Center for Disease Control and Prevention, Jinzhou, China.
Xuan ZhangDepartment of Toxicology, School of Public health, China Medical University, Shenyang, China.
Xichang WangDepartment of Toxicology, School of Public health, China Medical University, Shenyang, China.ORCID 0000-0002-4115-3367
Peng QuDepartment of Toxicology, School of Public health, China Medical University, Shenyang, China.
Yuejiao ZhaoDepartment of head and Neck Surgery, Cancer Hospital of China Medical University/Liaoning Cancer Hospital & Institute, Shenyang, China.
Xiaobo LuDepartment of Toxicology, School of Public health, China Medical University, Shenyang, China.ORCID 0000-0002-3136-9439
China Medical University · CNTaiwan Centers for Disease Control · TWLiaoning Cancer Hospital & Institute · CN

Funding

Liaoning Provincial Key Research and Development Program 2017225056Liaoning Provincial Key Research and Development Program ZF2019034National Cancer Center's "Climbing" Program NCC201806B009National Natural Science Foundation of China 81773470Provincial Natural Science Foundation of Liaoning 2019-ZD-0595
6 · The paper itself

Abstract

Bisphenol A (BPA), a ubiquitous endocrine-disrupting chemical, alters the function of endocrine system and enhances the susceptibility to tumorigenesis in several hormone-dependent tumours as thyroid carcinoma. About 50% of papillary thyroid cancers (PTC), the most common type of thyroid malignancy, harbours the BRAF

Indexed as

MutationAdultAgedAir Pollutants, OccupationalAllelesBenzhydryl CompoundsBiomarkers, TumorBisphenol A CompoundsCell MovementEpithelial-Mesenchymal TransitionEstrogens, Non-SteroidalFemaleHumansImmunohistochemistryMaleMAP Kinase Signaling SystemAir Pollutants, OccupationalBenzhydryl CompoundsBiomarkers, Tumorbisphenol ABisphenol A CompoundsBRAF protein, humanEstrogens, Non-SteroidalPhenolsProto-Oncogene Proteins B-rafBisphenol ABRAFV600E mutationepithelial-mesenchymal transitionERK-Cox2Papillary thyroid carcinoma

Identifiers

PMID33469997
PMCPMC7875916
OpenAlexW3124105466

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.