Evidence map›Paper›PMID 33469989›Full record

ArticleMolecular oncology2021

REST promotes ETS1-dependent vascular growth in medulloblastoma.

Shavali Shaik, Shinji Maegawa, Amanda R Haltom, Feng Wang, Xue Xiao, Tara Dobson, Ajay Sharma, Yanwen Yang, Jyothishmathi Swaminathan, Vikas Kundra and 5 more

Open access · goldAbstract read
In one paragraph

Article in Molecular oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. Article
  13. Review
  14. Medulloblastoma: novel insights into emerging therapeutic targets.Expert opinion on therapeutic targets · 2021
    Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 1 country.

Shavali ShaikDepartment of Pediatrics, University of Texas, MD Anderson Cancer Center, Houston, TX, USA.
Shinji MaegawaDepartment of Pediatrics, University of Texas, MD Anderson Cancer Center, Houston, TX, USA.
Amanda R HaltomDepartment of Pediatrics, University of Texas, MD Anderson Cancer Center, Houston, TX, USA.
Feng WangDepartment of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Xue XiaoDepartment of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Tara DobsonDepartment of Pediatrics, University of Texas, MD Anderson Cancer Center, Houston, TX, USA.
Ajay SharmaDepartment of Pediatrics, University of Texas, MD Anderson Cancer Center, Houston, TX, USA.
Yanwen YangDepartment of Pediatrics, University of Texas, MD Anderson Cancer Center, Houston, TX, USA.
Jyothishmathi SwaminathanDepartment of Pediatrics, University of Texas, MD Anderson Cancer Center, Houston, TX, USA.
Vikas KundraDepartments of Abdominal Imaging and Cancer Systems, University of Texas, MD Anderson Cancer Center, Houston, TX, USA.
Xiao Nan LiDepartment of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Keri SchadlerDepartment of Pediatrics, University of Texas, MD Anderson Cancer Center, Houston, TX, USA.
Arif HarmanciCenter for Precision Health, School of Biomedical Informatics, The University of Texas Health Science Center, Houston, TX, USA.
Lin XuDepartment of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Vidya GopalakrishnanDepartment of Pediatrics, University of Texas, MD Anderson Cancer Center, Houston, TX, USA.ORCID 0000-0002-4448-4698
The University of Texas MD Anderson Cancer Center · USThe University of Texas Southwestern Medical Center · USNorthwestern University · USThe University of Texas Health Science Center · US

Funding

Study of a Novel Deubiquitylase in MedulloblastomaR01NS079715 · NINDS · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI GOPALAKRISHNAN, VIDYA · 2012 to 2015
$1.4M
Development of Novel Mouse Models to Study REST Function in MedulloblastomaR03NS077021 · NINDS · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI GOPALAKRISHNAN, VIDYA · 2011 to 2012
$158k
NINDS NIH HHS R01 NS079715NINDS NIH HHS R03 NS077021
6 · The paper itself

Abstract

Expression of the RE1-silencing transcription factor (REST), a master regulator of neurogenesis, is elevated in medulloblastoma (MB) tumors. A cell-intrinsic function for REST in MB tumorigenesis is known. However, a role for REST in the regulation of MB tumor microenvironment has not been investigated. Here, we implicate REST in remodeling of the MB vasculature and describe underlying mechanisms. Using REST

Indexed as

AnimalsCell ProliferationCells, CulturedCerebellar NeoplasmsHumansHuman Umbilical Vein Endothelial CellsMedulloblastomaMiceMice, Inbred NODMice, SCIDMice, TransgenicNeovascularization, PathologicProto-Oncogene Protein c-ets-1RE1-Silencing Transcription FactorRepressor ProteinsTumor MicroenvironmentETS1 protein, humanProto-Oncogene Protein c-ets-1RE1-Silencing Transcription FactorRepressor ProteinsmedulloblastomaNRSFRESTtumor microenvironmentvasculature

Identifiers

PMID33469989
PMCPMC8096796
OpenAlexW3125140545

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.