Evidence map›Paper›PMID 33469948›Full record

ArticleJournal of medical primatology2021

Comparative computer-assisted sperm analysis in non-human primates.

Jenna K Schmidt, Katherine D Mean, Brittany M Dusek, Hayly M Hinkle, Riley C Puntney, Eric S Alexander, Kerri B Malicki, Emily L Sneed, Amy W Moy, Thaddeus G Golos

Open access · greenAbstract read
In one paragraph

Article in Journal of medical primatology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Non-human primate: the new frontier model of female reproductive engineering.Frontiers in bioengineering and biotechnology · 2025
    Review
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Jenna K SchmidtWisconsin National Primate Research Center, Madison, WI, USA.ORCID 0000-0002-9092-8739
Katherine D MeanWisconsin National Primate Research Center, Madison, WI, USA.
Brittany M DusekWisconsin National Primate Research Center, Madison, WI, USA.
Hayly M HinkleWisconsin National Primate Research Center, Madison, WI, USA.
Riley C PuntneyWisconsin National Primate Research Center, Madison, WI, USA.
Eric S AlexanderWisconsin National Primate Research Center, Madison, WI, USA.
Kerri B MalickiWisconsin National Primate Research Center, Madison, WI, USA.
Emily L SneedWisconsin National Primate Research Center, Madison, WI, USA.
Amy W MoyWisconsin National Primate Research Center, Madison, WI, USA.
Thaddeus G GolosWisconsin National Primate Research Center, Madison, WI, USA.
University of Wisconsin–Madison · US

Funding

WNPRC Supplemental Request for Nonhuman Primate Enclosures to Equip HIV/AIDS-Related Research FacilitiesP51OD011106 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI Dorota A. Grejner-Brzezinska · 2012 to 2026
$150.7M
EXTRAMURAL RES FACIL CONST: REPRODUCTIVE, GROWTH &DVMT, MENOPAUSEC06RR020141 · NCRR · UNIVERSITY OF WISCONSIN MADISON · PI CADWALLADER, MARTIN · 2004 to 2004
$3.6M
EXTRAMURAL REGIONAL FACILITIES CONSTRUCTIONC06RR015459 · NCRR · UNIVERSITY OF WISCONSIN MADISON · PI CADWALLADER, MARTIN · 2000 to 2000
$1.9M
Primate-specific miRNAs in Embryonic and Placental DevelopmentK99HD099154 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI SCHMIDT, JENNA ANN · 2019 to 2021
$228k
NCRR NIH HHS C06 RR015459NCRR NIH HHS C06 RR020141NICHD NIH HHS K99 HD099154NIH HHS P51 OD011106NIH HHS RR15459-01 and RR020141-01
6 · The paper itself

Abstract

backgroundBiomedical research has recently focused on developing new models of human disease by implementing genome-editing strategies in non-human primates (NHPs) to introduce relevant gene mutations. There is a need to establish objective semen evaluation methods to select sires for in vitro fertilization to perform germline editing in embryos.

methodsSperm motility kinematic parameters were evaluated using a computer-assisted semen analysis (CASA) instrument for rhesus macaques (Macaca mulatta), cynomolgus macaques (Macaca fascicularis), and common marmosets (Callithrix jacchus).

resultsNormative sperm kinematic parameters were established, revealing differences between marmosets and macaques. The impact of season on rhesus macaque sperm motility was modest, where changes in sperm motility related to season were dependent on the individual male.

conclusionsThese data provide a baseline of normative kinematic parameters for three captive NHP species, in which implementation of CASA may serve as a tool to evaluate NHP semen quality.

Indexed as

Sperm MotilityAnimalsBiomechanical PhenomenaCallithrixMacaca fascicularisMacaca mulattaMaleSemen AnalysisSpecies SpecificitySpermatozoaCASAmacaquemarmosetsperm

Identifiers

PMID33469948
PMCPMC7969417
OpenAlexW3122948503

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.