Evidence map›Paper›PMID 33469859›Full record

ArticleObesity surgery2021

Intestinal Electrical Stimulation Enhances Release of Postprandial Incretin Hormones Via Cholinergic Mechanisms.

Yan Dong, Yiling Zhang, Shiying Li, Jiande D Z Chen

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Obesity surgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Yan Dong *Division of Gastroenterology and Hepatology, Johns Hopkins University, Baltimore, MD, 21224, USA.
Yiling Zhang *Division of Gastroenterology and Hepatology, Johns Hopkins University, Baltimore, MD, 21224, USA.
Shiying LiDivision of Gastroenterology and Hepatology, Johns Hopkins University, Baltimore, MD, 21224, USA.
Jiande D Z ChenDivision of Gastroenterology and Hepatology, Johns Hopkins University, Baltimore, MD, 21224, USA. CJiande@Umich.edu.ORCID http://orcid.org/0000-0001-6823-6253
Johns Hopkins University · US

Funding

University of Michigan Center for Gastrointestinal ResearchP30DK034933 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI OMARY, BISHR · 1986 to 2021
$22.5M
Electronic Bypass for DiabetesR01DK107754 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CHEN, JIANDE · 2018 to 2021
$1.8M
NIDDK NIH HHS P30 DK034933NIDDK NIH HHS R01 DK107754
6 · The paper itself

Abstract

introductionIntestinal electrical stimulation (IES) has been reported to reduce body weight and improve glucose tolerance in obese and diabetic rats. Our study aimed to investigate possible IES mechanisms involving incretin hormones using intraduodenal glucose infusion in rats. We hypothesized that the enhanced release of postprandial glucagon-like peptide-1 (GLP-1) at early phase by IES was mediated through neuro/paracrine mechanisms involving the vagal nerve and glucose-dependent insulinotropic peptide (GIP).

methodsFifteen normal male Sprague-Dawley rats chronically implanted with duodenal electrodes for IES, and an intra-duodenum catheter for the infusion of glucose were studied in a series of sessions with IES of different parameters with and without atropine and M3 receptor antagonist. Blood samples were collected via the tail vein for the measurement of blood glucose, and plasma GLP-1, and GIP.

results(1) Compared to sham-IES, IES of 0.3 ms reduced blood glucose by 16.5-28.4% between 30 and 120 min (all time points p < 0.05), and IES of 3-ms reduced blood glucose at 60 (12.6%) and 90 min (11.8%). IES of 0.3 ms showed a greater hypoglycemic effect than 3 ms (p = 0.024) at 30 min. (2) IES elevated plasma GLP-1 with 0.3 ms (p = 0.001) and with 3 ms p = 0.03). (3) IES substantially elevated plasma GIP with 0.3 ms (p = 0.002) and with 3 ms (p < 0.001). (4) Pretreatment of atropine and the M3 receptor antagonist 4-DAMP blocked the effects of IES on GLP-1, GIP, and blood glucose.

conclusionsIES reduces postprandial blood glucose by enhancing the release of GLP-1 and GIP mediated via the cholinergic mechanism.

Indexed as

Diabetes Mellitus, ExperimentalObesity, MorbidAnimalsBlood GlucoseCholinergic AgentsElectric StimulationGastric Inhibitory PolypeptideIncretinsInsulinMaleRatsRats, Sprague-DawleyBlood GlucoseCholinergic AgentsGastric Inhibitory PolypeptideIncretinsInsulinGIPGLP-1Incretin hormonesIntestinal electrical stimulationType 2 diabetes mellitus

Identifiers

PMID33469859
PMCPMC8393982
OpenAlexW3121130963

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.