Evidence map›Paper›PMID 33469830›Full record

Observational studyPituitary2021

Aerosolisation in endonasal endoscopic pituitary surgery.

Rana S Dhillon, Lana V Nguyen, Wagih Abu Rowin, Ruhi S Humphries, Kevin Kevin, Jason D Ward, Andrew Yule, Tuong D Phan, Yi Chen Zhao, David Wynne and 3 more

Open access · bronzeAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Pituitary, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Rana S DhillonDepartment of Neurosurgery, St Vincent's Hospital Melbourne, 41 Victoria Parade, Fitzroy, VIC, 3065, Australia. rana.dhillon@svha.org.au.ORCID http://orcid.org/0000-0002-6975-8325
Lana V NguyenDepartment of Neurosurgery, St Vincent's Hospital Melbourne, 41 Victoria Parade, Fitzroy, VIC, 3065, Australia.
Wagih Abu RowinDepartment of Mechanical Engineering, University of Melbourne, Grattan Street, Parkville, VIC, 3010, Australia.
Ruhi S HumphriesClimate Science Centre, CSIRO Oceans and Atmosphere, 107 Station Street, Aspendale, VIC, 3195, Australia.
Kevin KevinDepartment of Mechanical Engineering, University of Melbourne, Grattan Street, Parkville, VIC, 3010, Australia.
Jason D WardClimate Science Centre, CSIRO Oceans and Atmosphere, 107 Station Street, Aspendale, VIC, 3195, Australia.
Andrew YuleARPANSA (Australian Radiation Protection and Nuclear Safety Agency), 619 Lower Plenty Road, Yallambie, VIC, 3085, Australia.
Tuong D PhanDepartment of Anaesthesia and Acute Pain Medicine, St Vincent's Hospital Melbourne, 41 Victoria Parade, Fitzroy, VIC, 3065, Australia.
Yi Chen ZhaoDepartment of Ear, Nose and Throat Surgery, St Vincent's Hospital Melbourne, 41 Victoria Parade, Fitzroy, VIC, 3065, Australia.
David WynneDepartment of Neurosurgery, St Vincent's Hospital Melbourne, 41 Victoria Parade, Fitzroy, VIC, 3065, Australia.
Peter M McNeillDepartment of Neurosurgery, St Vincent's Hospital Melbourne, 41 Victoria Parade, Fitzroy, VIC, 3065, Australia.
Nicholas HutchinsDepartment of Mechanical Engineering, University of Melbourne, Grattan Street, Parkville, VIC, 3010, Australia.
David A ScottDepartment of Anaesthesia and Acute Pain Medicine, St Vincent's Hospital Melbourne, 41 Victoria Parade, Fitzroy, VIC, 3065, Australia.
St Vincent's Hospital Melbourne · AUThe University of Melbourne · AUCSIRO Oceans and Atmosphere · AUAustralian Radiation Protection and Nuclear Safety Agency

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo determine the particle size, concentration, airborne duration and spread during endoscopic endonasal pituitary surgery in actual patients in a theatre setting.

methodsThis observational study recruited a convenience sample of three patients. Procedures were performed in a positive pressure operating room. Particle image velocimetry and spectrometry with air sampling were used for aerosol detection.

resultsIntubation and extubation generated small particles (< 5 µm) in mean concentrations 12 times greater than background noise (p < 0.001). The mean particle concentrations during endonasal access were 4.5 times greater than background (p = 0.01). Particles were typically large (> 75 µm), remained airborne for up to 10 s and travelled up to 1.1 m. Use of a microdebrider generated mean aerosol concentrations 18 times above baseline (p = 0.005). High-speed drilling did not produce aerosols greater than baseline. Pituitary tumour resection generated mean aerosol concentrations less than background (p = 0.18). Surgical drape removal generated small and large particles in mean concentrations 6.4 times greater than background (p < 0.001).

conclusionIntubation and extubation generate large amounts of small particles that remain suspended in air for long durations and disperse through theatre. Endonasal access and pituitary tumour resection generate smaller concentrations of larger particles which are airborne for shorter periods and travel shorter distances.

Indexed as

AerosolsAirway ExtubationEndoscopyHumansIntubation, IntratrachealMotionOccupational ExposureOccupational HealthOperating RoomsParticle SizePituitary NeoplasmsProspective StudiesRisk AssessmentRisk FactorsTime FactorsAerosolsAerosol-generating procedureAerosolsCOVID-19Endonasal endoscopic pituitary surgeryOccupational exposure

Identifiers

PMID33469830
PMCPMC7814858
OpenAlexW3121769674

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.